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Nature Communications is an online-only, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, physical and chemical sciences. Papers published by the journal represent important advances of significa

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Concept neurons in the human medial temporal lobe flexibly represent abstract relations between concepts

Nature Communications, Published online: 25 October 2021; doi:10.1038/s41467-021-26327-3It is unclear how distinct concepts are processed in the brain. Here, the authors recorded from concept cells in human subjects with epilepsy and found that a subset of concept cells responded to non-preferred concepts if those non-preferred concepts required comparison...

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

Nature Communications, Published online: 25 October 2021; doi:10.1038/s41467-021-26409-2The recently identified Wuhan spiny eel influenza virus (WSEIV) sequence is more closely related to influenza B than A viruses. Here, the authors functionally characterize the putative surface glycoproteins of WSEIV and show that its NA-like protein has sialidase...

Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform

Nature Communications, Published online: 25 October 2021; doi:10.1038/s41467-021-26496-1Investigations of human cardiac disease involving human pluripotent stem cell-derived cardiomyocytes are limited by the disorganized presentation of biomechanical cues resulting in cell immaturity. Here the authors develop a platform of micron-scale 2D cardiac muscle...

Bottom-up modular synthesis of well-defined oligo(arylfuran)s

Nature Communications, Published online: 25 October 2021; doi:10.1038/s41467-021-26387-5Oligofurans have attracted great attention because of their strong fluorescence, charge delocalization, and increased solubility. Here the authors show a bottom-up modular construction of chemically and structurally well-defined oligo(arylfuran)s by de novo synthesis...

Structure of Machupo virus polymerase in complex with matrix protein Z

Nature Communications, Published online: 25 October 2021; doi:10.1038/s41467-021-26432-3The RNA polymerase L of arenaviruses is of interest for drug design and its activity is inhibited by the matrix protein Z. Here, the authors present the cryo-EM structure of the Machupo virus polymerase L in complex with matrix protein Z and discuss the inhibitory...

Antibiotic-chemoattractants enhance neutrophil clearance of <i>Staphylococcus aureus</i>

Nature Communications, Published online: 25 October 2021; doi:10.1038/s41467-021-26244-5Antibiotic resistance in Staphylococcus aureus is associated with reduced neutrophil recruitment. Here, Payne et al. link formylated peptides, which act as chemoattractants for neutrophils, with the antibiotic vancomycin and show that these hybrid compounds improve...

Aging power spectrum of membrane protein transport and other subordinated random walks

Nature Communications, Published online: 25 October 2021; doi:10.1038/s41467-021-26465-8Experimental data obtained in single-particle tracking experiments are challenging to interpret. The authors propose an approach for determining the dynamics of the stochastic motion of molecules based on the power spectrum, relevant to various non-stationary scale-free...

Elimination of oxygen sensitivity in <i>α</i>-titanium by substitutional alloying with Al

Nature Communications, Published online: 25 October 2021; doi:10.1038/s41467-021-26374-wIndividual addition of O or Al is known to deteriorate ductility of Ti alloys, especially at cryogenic temperatures. Here the authors demonstrate a counter-intuitive effect where significant addition of both Al and O substantially improves both strength and ductility...

The flashfm approach for fine-mapping multiple quantitative traits

Nature Communications, Published online: 22 October 2021; doi:10.1038/s41467-021-26364-yGenetic signals from quantitative traits could be a challenge to finemap. Flashfm uses summary-level data in a Bayesian framework to favour shared causal variants and capitalises on information between traits, providing an accurate and efficient joint fine-mapping...

Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy

Nature Communications, Published online: 22 October 2021; doi:10.1038/s41467-021-26380-yThe hydroxyl radical is generated during radiotherapy and ferroptosis and accurate imaging of this reactive oxygen species may permit the monitoring of response to therapy. Here, the authors develop a ratiometric probe for accurate imaging of hydroxyl radical generation...

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