High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17209-1Reliable, multiplexed gene editing to uncover synergies between targets remains challenging. Here, the authors engineer AsCas12a and the crRNA to improve double knockout for synthetic sick/lethal interaction genetic screening.

2h

Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons

Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17270-wThe vCA1-BA projection is enriched in shock responsive neurons, which are necessary for fear memory encoding and become correlated with a network of neurons during retrieval. Here the authors show that the magnitude of vCA1 correlated activity is proportional to memory...

8h

Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death

Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17300-7It is unclear whether 2D metal dichalcogenides (TMD) alone can cause ferroptotic cell death. Here, the authors show TMD nanosheets induced ferroptosis in mammalian cell lines and in a mouse model after aspiration of TMD materials into lungs, causing ferroptotic cell...

8h

Neural circuits in the mouse retina support color vision in the upper visual field

Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17113-8Mice are able to discriminate colors, at least in the upper visual field. Here, the authors provide a comprehensive characterization of retinal circuits underlying this behavior.

8h

Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins

Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17212-6Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity of these force generators...

8h

Brain meta-state transitions demarcate thoughts across task contexts exposing the mental noise of trait neuroticism

Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17255-9Explicit self-reflection is unreliable for measuring thoughts. Here, the authors use brain data to implicitly pinpoint transitions between thoughts and find thought turnover to be reliably predicted by narrative events during movie-viewing, as well as by greater trait...

8h

Imaging electrochemically synthesized Cu₂O cubes and their morphological evolution under conditions relevant to CO₂ electroreduction

Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17220-6Catalytic selectivity during carbon dioxide electroreduction can be tuned by using geometric copper-based catalysts. Here, the authors use liquid cell transmission electron microscopy to study the in situ synthesis and morphological evolution Cu2O cubes under carbon...

8h

Non-monotonic pressure dependence of high-field nematicity and magnetism in CeRhIn₅

Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17274-6Multiple quantum critical behaviors exist in the heavy fermion material CeRhIn5, but their interrelation is less studied. Here, Helm et al. investigate the interrelation of two quantum critical points and other relevant orders, revealing a strongly non-mean-field-like...

8h

Meta-analysis of multidecadal biodiversity trends in Europe

Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17171-yThe global biodiversity decline might conceal complex local and group-specific trends. Here the authors report a quantitative synthesis of longterm biodiversity trends across Europe, showing how, despite overall increase in biodiversity metric and stability in abundance,...

8h

Spatial defects nanoengineering for bipolar conductivity in MoS₂

Nature Communications, Published online: 10 July 2020; doi:10.1038/s41467-020-17241-1Bipolar conductivity is fundamental for electronic devices based on two-dimensional semiconductors. Here, the authors report on-demand p- and n-doping of monolayer MoS2 via defects engineering using thermochemical scanning probe lithography, and achieve a p-n junction...

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