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Nature Neuroscience - Issue - nature.com science feeds

Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.

Latest articles

A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice

Nature Neuroscience, Published online: 01 June 2020; doi:10.1038/s41593-020-0640-8An et al. discovered a new brain pathway in mice that conveys light signals from the retina to mood-relevant subcortical nuclei under circadian gating and thereby mediates depressive-like behaviors induced by abnormal nighttime light exposure.

Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1

Nature Neuroscience, Published online: 25 May 2020; doi:10.1038/s41593-020-0642-6Shen et al. report that prolonged obesity is associated with cerebrovascular dysfunction and Tak1 activation in brainstem microglia. Pharmacological inhibition or genetic depletion of Tak1 restores cerebrovascular function in obese mice.

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

Nature Neuroscience, Published online: 25 May 2020; doi:10.1038/s41593-020-0643-5A genetic study of problematic alcohol use in 435,563 individuals, including data from the Million Veteran Program, Psychiatric Genomics Consortium and UK Biobank, found many novel risk loci and provided new insights into trait biology.

Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning

Nature Neuroscience, Published online: 25 May 2020; doi:10.1038/s41593-020-0647-1Learning new associations that reappraise the behavioral significance of previously irrelevant cues requires gamma-frequency synchronization between parvalbumin interneurons in the left and right prefrontal cortex.

Assessing the depth of language processing in patients with disorders of consciousness

Nature Neuroscience, Published online: 25 May 2020; doi:10.1038/s41593-020-0639-1Assessing residual consciousness in unresponsive patients is a major clinical concern. Gui et al. demonstrate that EEG-based language assessment can objectively characterize states of consciousness and predict outcomes in individual patients.

Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression

Nature Neuroscience, Published online: 25 May 2020; doi:10.1038/s41593-020-0634-6This study elucidates how long-range chromatin loops are altered during short- and long-term changes in neural activity, and analyzes the interplay between the 3D genome and the linear epigenome during activity-dependent transcriptional responses.

Membrane potential dynamics underlying context-dependent sensory responses in the hippocampus

Nature Neuroscience, Published online: 25 May 2020; doi:10.1038/s41593-020-0646-2Place cell responses are strongly modulated by context, allowing the hippocampus to effectively encode different environments. Electrical recordings show that the context-dependent representation of environmental features is present in the CA3 subregion and is inherited...

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

Nature Neuroscience, Published online: 18 May 2020; doi:10.1038/s41593-020-0635-5Proteome-wide association studies of brain samples from older adults revealed effects of cerebral atherosclerosis and Alzheimer’s disease. A subset of proteins and protein co-expression modules were associated with both, suggesting shared mechanisms.

General anesthetics activate a potent central pain-suppression circuit in the amygdala

Nature Neuroscience, Published online: 18 May 2020; doi:10.1038/s41593-020-0632-8Hua and Chen et al. show that general anesthesia activates a distinct population of central amygdala neurons and that these neurons can potently suppress pain responses through their widespread projections to many pain-processing centers in the brain.

Anesthesia analgesia in the amygdala

Nature Neuroscience, Published online: 18 May 2020; doi:10.1038/s41593-020-0645-3General anesthetics during surgery are presumed to block pain by dampening brain activity and promoting loss-of-consciousness. A new study shows that anesthetics activate an endogenous analgesia neural ensemble in the central nucleus of the amygdala.

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