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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.

Latest articles

Magnetic signatures of brain health characterized in UK Biobank population imaging study

Nature Neuroscience, Published online: 23 May 2022; doi:10.1038/s41593-022-01083-9Myelin, iron, and calcium are major constituents of brain tissue with magnetic properties that can be detected non-invasively using MRI. Using quantitative susceptibility mapping, we estimated the magnetic susceptibility of brain structures in 35,273 participants, creating...

Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging

Nature Neuroscience, Published online: 23 May 2022; doi:10.1038/s41593-022-01074-wWang et al. present a new open resource from the UK Biobank using quantitative susceptibility mapping, a neuroimaging marker sensitive to iron and myelin. They demonstrate a broad range of phenotypic and genetic associations in 35,885 participants.

Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function

Nature Neuroscience, Published online: 19 May 2022; doi:10.1038/s41593-022-01072-yBenoit et al. show that inhibition of the thalamus during adolescence leads to long-lasting changes in prefrontal cortex function and behavior, demonstrating the importance of adolescent thalamic activity for prefrontal circuit maturation.

John Q. Trojanowski, ‘tour de force’ in neurodegeneration (1946–2022)

Nature Neuroscience, Published online: 19 May 2022; doi:10.1038/s41593-022-01087-5John Q. Trojanowski, ‘tour de force’ in neurodegeneration (1946–2022)

Meta-matching as a simple framework to translate phenotypic predictive models from big to small data

Nature Neuroscience, Published online: 16 May 2022; doi:10.1038/s41593-022-01059-9Individual-level prediction is critical for precision medicine, but many neuroimaging prediction studies are underpowered. Here the authors present a simple yet powerful approach that effectively translates predictive models from big to small data.

Candelabrum cells are ubiquitous cerebellar cortex interneurons with specialized circuit properties

Nature Neuroscience, Published online: 16 May 2022; doi:10.1038/s41593-022-01057-xCandelabrum cells have remained an obscure cerebellar cell type. The authors show that candelabrum cells are the most abundant Purkinje layer interneuron, are molecularly distinct and have a connectivity that allows them to control cerebellar output.

Piggybacking on big data

Nature Neuroscience, Published online: 16 May 2022; doi:10.1038/s41593-022-01058-wA new ‘meta-matching’ algorithm developed by He et al., published in this issue of Nature Neuroscience, enables small MRI datasets to piggyback on larger datasets to boost prediction accuracy. This innovation may aid in efforts toward personalized psychiatry.

Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system

Nature Neuroscience, Published online: 06 May 2022; doi:10.1038/s41593-022-01063-zThis study finds that during acute viral infection of the CNS, meningeal lymphatic vessels (MLVs) can transport virus from the CNS to draining cervical lymph nodes. VEGF-C-induced expansion of functional MLVs facilitated virus clearance.

Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury

Nature Neuroscience, Published online: 06 May 2022; doi:10.1038/s41593-022-01067-9Bertels et al. identify that spinal neurons switch neurotransmitter phenotype from excitation to inhibition after spinal cord injury. Manipulation of neurotransmitter phenotype reveals that maintaining excitatory phenotype is essential for locomotor recovery.

Grids and the city

Nature Neuroscience, Published online: 06 May 2022; doi:10.1038/s41593-022-01078-6Grids and the city

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