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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.

Latest articles

Author Correction: A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

Nature Neuroscience, Published online: 31 January 2023; doi:10.1038/s41593-023-01266-yAuthor Correction: A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain

Nature Neuroscience, Published online: 23 January 2023; doi:10.1038/s41593-022-01250-yZhou et al. show that the generation and maintenance of chronic neuropathic pain after peripheral nerve injury is crucially dependent on the activation of a parabrachial nucleus–nucleus basalis-S1 pathway during non-REM sleep.

Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein

Nature Neuroscience, Published online: 23 January 2023; doi:10.1038/s41593-022-01239-7Pathological α-synuclein (α-Syn) spreading is critical for the progression of many neurodegenerative diseases. The authors demonstrate that soluble α-Syn post-translational modifications (PTMs) dramatically modulate pathological α-synuclein spreading.

Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks

Nature Neuroscience, Published online: 23 January 2023; doi:10.1038/s41593-022-01244-wThis study shows that pyramidal tract (PT) and intratelencephalic (IT) projection neurons process information via distinct parallel subnetworks across cortex, each preferentially associated with either motor events or sensorimotor transformation.

Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making

Nature Neuroscience, Published online: 23 January 2023; doi:10.1038/s41593-022-01245-9Distinct cortical pyramidal neuron types, defined by developmental lineage, make unique contributions to behavioral decisions. We highlight the importance of interactions among diverse cortical and subcortical areas for successful decision outcomes.

Massively parallel identification of mRNA localization elements in primary cortical neurons

Nature Neuroscience, Published online: 16 January 2023; doi:10.1038/s41593-022-01243-xThe authors established a method to map RNA localization sequences (zipcodes) and identified the let-7 site and AU repeat as new zipcodes in primary cortical neurons.

A neural substrate of sex-dependent modulation of motivation

Nature Neuroscience, Published online: 16 January 2023; doi:10.1038/s41593-022-01229-9The authors show that action value modulates motivation to perform a decision-making task more strongly in females than in males. Anterior cingulate cortex neurons that project to the striatum contribute to this sex difference.

Blood-to-brain communication in aging and rejuvenation

Nature Neuroscience, Published online: 16 January 2023; doi:10.1038/s41593-022-01238-8In this Review, Villeda and colleagues describe blood-to-brain communication from a systems physiology perspective, with an emphasis on blood-derived signals as potent drivers of both age-related brain dysfunction and brain rejuvenation.

Residual dynamics resolves recurrent contributions to neural computation

Nature Neuroscience, Published online: 12 January 2023; doi:10.1038/s41593-022-01230-2Activity in a neural population arises from both its inputs and its recurrent connections. Here the authors show that analyzing the dynamics of trial-to-trial variability in activity can offer insights into delineating these contributions.

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Nature Neuroscience, Published online: 12 January 2023; doi:10.1038/s41593-022-01240-0van Lengerich et al. developed a human TREM2 antibody with a transport vehicle (ATV) that improves brain exposure and biodistribution in mouse models. ATV:TREM2 promotes microglial energetic capacity and metabolism via mitochondrial pathways.

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