Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories

Nature Neuroscience, Published online: 23 February 2024; doi:10.1038/s41593-024-01586-7Sias et al. show that dopamine projections to the basolateral amygdala drive the reward learning that supports the predictions and inferences needed for adaptive decision-making.

Fri Feb 23, 2024 13:31
Mapping the dysfunctome provides an avenue for targeted brain circuit therapy

Nature Neuroscience, Published online: 22 February 2024; doi:10.1038/s41593-024-01572-zBrain connections modulated by 534 deep-brain-stimulation electrodes revealed a gradient of circuits involved in dystonia, Parkinson’s disease, Tourette’s syndrome and obsessive-compulsive disorder. Together, these circuits begin to describe the human ‘dysfunctome’,...

Thu Feb 22, 2024 19:03
Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation

Nature Neuroscience, Published online: 22 February 2024; doi:10.1038/s41593-024-01570-1Hollunder et al. identify networks where deep brain stimulation reduces symptoms for Parkinson’s disease, Tourette’s syndrome, dystonia and obsessive-compulsive disorder. This revealed a fronto-rostral topography that segregates the frontal cortex.

Thu Feb 22, 2024 19:03
Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Nature Neuroscience, Published online: 22 February 2024; doi:10.1038/s41593-024-01576-9Long COVID is a major public health issue since 2020 and exhibits frequent neurological symptoms. Greene et al. propose that brain fog results from leaky brain blood vessels and a hyperactive immune system, shedding light on this phenomenon.

Thu Feb 22, 2024 12:52
Leaky blood–brain barrier in long-COVID-associated brain fog

Nature Neuroscience, Published online: 22 February 2024; doi:10.1038/s41593-024-01577-8Long COVID has remained an on-going public health issue in the years following the global pandemic. Here, we report blood–brain barrier disruption in patients with acute SARS-CoV-2 infection and brain fog, and patients presenting with long COVID, brain fog and cognitive...

Thu Feb 22, 2024 12:52
A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity

Nature Neuroscience, Published online: 20 February 2024; doi:10.1038/s41593-024-01580-zAstrocytes have important roles in disease. However, modulation of their reactive state is challenging. Here the authors present a phenotypic in vitro screening platform they can leverage to identify chemical compounds able to modulate astrocyte reactivity in vitro...

Tue Feb 20, 2024 12:59

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