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Nature Neuroscience - Issue - nature.com science feeds - RSS Feed

Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.

Latest articles

Two-faced behavior of microglia in Alzheimer’s disease

Nature Neuroscience, Published online: 23 November 2021; doi:10.1038/s41593-021-00963-wMicroglia form barriers that attenuate the propagation of amyloid pathology in Alzheimer’s disease. d’Errico et al. have uncovered a paradoxical ability of microglia to spread amyloid plaques, which depends on the transcription factor IRF8. Here, we highlight the...

Microglia contribute to the propagation of Aβ into unaffected brain tissue

Nature Neuroscience, Published online: 22 November 2021; doi:10.1038/s41593-021-00951-0This study shows that Aβ from transgenic host tissue is able to enter and deposit within wild-type grafts via microglia, thus identifying microglia as carriers of Aβ deposition into previously unaffected brain tissue.

Ventral striatal islands of Calleja neurons control grooming in mice

Nature Neuroscience, Published online: 18 November 2021; doi:10.1038/s41593-021-00952-zDespite their discovery in the 19th century, the islands of Calleja, clusters of densely packed granule cells in the ventral striatum, remain enigmatic. This study reveals that islands of Calleja neurons are critical for grooming control in mice.

GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation

Nature Neuroscience, Published online: 18 November 2021; doi:10.1038/s41593-021-00960-zGnRH neurons control their own connectivity and function as well as the sexual maturation of the individual by using prostaglandin D2 DP1 signaling to recruit and stably associate with newborn astrocytes in the preoptic region during infancy in rodents.

Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence

Nature Neuroscience, Published online: 15 November 2021; doi:10.1038/s41593-021-00949-8Zhang et al. show that astrocytes develop responses to fear-conditioned auditory stimuli mediated by α7-nicotinic acetylcholine receptors (nAChRs) and that astrocytic α7-nAChRs in the auditory cortex are required for memory persistence and retrieval.

Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

Nature Neuroscience, Published online: 15 November 2021; doi:10.1038/s41593-021-00944-zBy comparing human induced pluripotent stem cell-derived spinal and ocular motor neurons, the authors identify low levels of a natural 5-lipoxygenase inhibitor in amyotrophic lateral sclerosis (ALS) spinal motor neurons. Functional analogs of 5-lipoxygenase inhibitors...

Corticothalamic feedback sculpts visual spatial integration in mouse thalamus

Nature Neuroscience, Published online: 11 November 2021; doi:10.1038/s41593-021-00943-0The authors show that retinotopically organized feedback from the primary visual cortex sharpens receptive fields and contributes to surround suppression in mouse visual thalamus, probably by recruiting inhibition through the thalamic reticular nucleus.

A data-driven framework for mapping domains of human neurobiology

Nature Neuroscience, Published online: 11 November 2021; doi:10.1038/s41593-021-00948-9Beam et al. created a data-driven mapping of human brain function, drawing on full texts and coordinate data reported in neuroimaging studies. This validated framework outperformed leading and widely used knowledge frameworks, namely Research Domain Criteria (RDoC)...

Re-conceptualizing domains in neuroscience, hopes and utopias aside

Nature Neuroscience, Published online: 11 November 2021; doi:10.1038/s41593-021-00946-xDescribing cognitive processes without reference to their neural underpinnings has led to conceptualizations that do not match how the brain functions. A data-driven re-examination of the neuroimaging literature reveals an alternate conceptual framework combining...

Magnetic resonance-based eye tracking using deep neural networks

Nature Neuroscience, Published online: 08 November 2021; doi:10.1038/s41593-021-00947-wViewing behavior is a key variable of interest but also a confound in fMRI studies. This paper presents a deep learning framework to decode gaze position from the magnetic resonance signal of the eyeballs, which enables eye tracking in fMRI data without a camera.

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