pubmed: cell cycle arrest
Exp Parasitol. 2024 May 7:108773. doi: 10.1016/j.exppara.2024.108773. Online ahead of print.ABSTRACTGiardiasis is a prevalent parasitic diarrheal disease caused by Giardia lamblia, affecting people worldwide. Recently, the availability of several drugs for its treatment has highlighted issues such as multidrug resistance, limited effectiveness and undesirable...
J Appl Toxicol. 2024 May 9. doi: 10.1002/jat.4620. Online ahead of print.ABSTRACTDietary supplements containing usnic acid have been increasingly marketed for weight loss over the past decades, even though incidences of severe hepatotoxicity and acute liver failure due to their overuse have been reported. To date, the toxic mechanism of usnic acid-induced...
Phytomedicine. 2024 May 5;129:155714. doi: 10.1016/j.phymed.2024.155714. Online ahead of print.ABSTRACTBACKGROUND: Temozolomide (TMZ) resistance is the main obstacle faced by glioblastoma multiforme (GBM) treatment. Muscone, one of the primary active pharmacological ingredients of Shexiang (Moschus), can cross the blood-brain barrier (BBB) and is being...
AAPS PharmSciTech. 2024 May 9;25(5):104. doi: 10.1208/s12249-024-02817-7.ABSTRACTSalinomycin (Sal) has been recently discovered as a novel chemotherapeutic agent against various cancers including prostate cancer which is one of the most commonly diagnosed cancers affecting male populations worldwide. Herein we designed salinomycin nanocarrier (Sal-NPs)...
Radiat Res. 2024 May 9. doi: 10.1667/RADE-23-00213.1. Online ahead of print.ABSTRACTRadiotherapy with cell cycle-specific anticancer agents has become an important option in the control of both primary tumors and metastases. Here, we used image analysis algorithms that enable quick segmentation and tracking to describe a radiobiological approach for...
Eur J Med Res. 2024 May 8;29(1):272. doi: 10.1186/s40001-024-01869-6.ABSTRACTBACKGROUND: Cell cycle protein-dependent kinase inhibitor protein 3 (CDKN3), as a member of the protein kinase family, has been demonstrated to exhibit oncogenic properties in several tumors. However, there are no pan-carcinogenic analyses for CDKN3.METHODS: Using bioinformatics...
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