J Acoust Soc Am. 2021 Sep;150(3):2131. doi: 10.1121/10.0006246.ABSTRACTSpeech perception (especially in background noise) is a critical problem for hearing-impaired listeners and an important issue for cognitive hearing science. Despite a plethora of standardized measures, few single-word closed-set tests uniformly sample the most frequently used phonemes...

Hear Res. 2021 Sep 20;411:108354. doi: 10.1016/j.heares.2021.108354. Online ahead of print.ABSTRACTComplex broadband sounds are decomposed by peripheral auditory filters into a series of relatively narrowband signals, each with a slowly varying envelope (ENV) and a rapidly fluctuating temporal fine structure (TFS). ENV and TFS information at the bilateral...

Antioxidants (Basel). 2021 Aug 25;10(9):1351. doi: 10.3390/antiox10091351.ABSTRACTStress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to sustained SAPK activation. Dusp1 gene knockout...

J Clin Oncol. 2021 Sep 27:JCO2100899. doi: 10.1200/JCO.21.00899. Online ahead of print.ABSTRACTPURPOSE: Hearing loss (HL) is a serious secondary effect of treatment for CNS and head-and-neck tumors in children. The goal of this study was to evaluate incidence and risk factors for HL in patients with multiple ototoxic exposures.PATIENTS AND METHODS:...

Int J Pharm X. 2021 Jul 2;3:100088. doi: 10.1016/j.ijpx.2021.100088. eCollection 2021 Dec.ABSTRACTCochlear implants containing iridium platinum electrodes are used to transmit electrical signals into the inner ear of patients suffering from severe or profound deafness without valuable benefit from conventional hearing aids. However, their placement...

J Neurophysiol. 2021 Sep 22. doi: 10.1152/jn.00131.2021. Online ahead of print.ABSTRACTExposure to 120 decibel sound pressure level (dB SPL) band-limited noise results in delayed onset latency and reduced vestibular short-latency evoked potential (VsEP) responses. These changes are still present four weeks after noise overstimulation. Noise induced...