Adv Drug Deliv Rev. 2022 Feb 2:114134. doi: 10.1016/j.addr.2022.114134. Online ahead of print.ABSTRACTPhotoimaging and phototherapy have become major platforms for the diagnosis and treatment of various health complications. These applications require a photosensitizer (PS) that is capable of absorbing light from a source and converting it into other...

Biomaterials. 2022 Jan 26;282:121381. doi: 10.1016/j.biomaterials.2022.121381. Online ahead of print.ABSTRACTPhotothermal therapy (PTT) has received increasing attention for treating tumors. However, a long-standing challenge in PTT is non-uniform distribution of photothermal agents (PAs) in tumor tissues, resulting in limited therapeutic efficiency....

Nat Protoc. 2022 Feb 4. doi: 10.1038/s41596-021-00665-4. Online ahead of print.ABSTRACTMacrophages in atherosclerotic lesions promote plaque progression and are an attractive therapeutic target in cardiovascular research. Here we present a protocol for synthesis of small interfering RNA (siRNA) nanoparticles (NP) that target lesional macrophages as...

J Nanobiotechnology. 2022 Feb 4;20(1):66. doi: 10.1186/s12951-022-01250-x.ABSTRACTThe engineered nanoformulation that can be activated by intracellular tumor microenvironment, including acidic pH, overexpressed H2O2, and high concentration of glutathione (GSH), features high efficacy to eradicate tumor cells with the intrinsic specificity and therapeutic...

World J Gastroenterol. 2022 Jan 14;28(2):176-187. doi: 10.3748/wjg.v28.i2.176.ABSTRACTHepatocellular carcinoma (HCC) is an epidemic burden and remains highly prevalent worldwide. The significant mortality rates of HCC are largely due to the tendency of late diagnosis and the multifaceted, complex nature of treatment. Meanwhile, current therapeutic modalities...

Nano Converg. 2022 Feb 4;9(1):7. doi: 10.1186/s40580-022-00297-8.ABSTRACTBioenzymes that catalyze reactions within living systems show a great promise for cancer therapy, particularly when they are integrated with nanoparticles to improve their accumulation into tumor sites. Nanomedicines can deliver toxic bioenzymes into cancer cells to directly cause...