JAMA Neurol. 2022 Jul 25:e221929. doi: 10.1001/jamaneurol.2022.1929. Online ahead of print.ABSTRACTIMPORTANCE: Except for ocrelizumab, treatment options in primary progressive multiple sclerosis (PPMS) are lacking.OBJECTIVE: To investigate the effectiveness of DMTs on the risk of becoming wheelchair dependent in a real-world population of patients with...

Nat Commun. 2022 Aug 11;13(1):4714. doi: 10.1038/s41467-022-32442-6.ABSTRACTGlutamate is a pivotal excitatory neurotransmitter in mammalian brains, but excessive glutamate causes numerous neural disorders. Almost all extracellular glutamate is retrieved by the glial transporter, Excitatory Amino Acid Transporter 2 (EAAT2), belonging to the SLC1A family....

Neuromuscul Disord. 2022 Jul 26:S0960-8966(22)00615-0. doi: 10.1016/j.nmd.2022.07.401. Online ahead of print.ABSTRACTPaediatric hyperCKaemia without weakness presents a clinical conundrum. Invasive investigations with low diagnostic yields, including muscle biopsy, may be considered unjustifiable. Improved access to genome-wide genetic testing has shifted...

J Neurol. 2022 Aug 8:1-9. doi: 10.1007/s00415-022-11295-5. Online ahead of print.ABSTRACTOBJECTIVE: An earlier follow-up study from the CogEx rehabilitation trial showed little change in symptoms of depression, anxiety and psychological distress during the first COVID-19 lockdown compared to pre-pandemic measurements. Here, we provide a second follow-up...

Nature. 2022 Aug 8. doi: 10.1038/s41586-022-05163-5. Online ahead of print.ABSTRACTIdentifying the factors underlying severe COVID-19 in the host genetics is an emerging issue1-5. We conducted a genome-wide association study (GWAS) involving 2,393 Japanese COVID-19 cases collected in initial pandemic waves with 3,289 controls, which identified a variant...

Biol Psychiatry. 2022 Jun 14:S0006-3223(22)01320-8. doi: 10.1016/j.biopsych.2022.06.005. Online ahead of print.ABSTRACTBACKGROUND: Visual impairment and interventions to preserve vision may impact dementia risk. Thus, we aimed to explore the associations of cataract and cataract surgery with the risk of dementia.METHODS: Prospective data from 300,823...