Mod Rheumatol. 2022 Aug 13:roac092. doi: 10.1093/mr/roac092. Online ahead of print.ABSTRACTOBJECTIVES: This multicenter, retrospective study evaluated the effectiveness of add-on methotrexate (MTX) or iguratimod (IGU) in patients with rheumatoid arthritis exhibiting an inadequate response to Janus kinase inhibitors (JAKi).METHODS: Forty-five patients...

Front Microbiol. 2022 Jul 22;13:932197. doi: 10.3389/fmicb.2022.932197. eCollection 2022.ABSTRACTBACKGROUND: Gut microbiota is a complex ecosystem that is vital for the development and function of the immune system, is closely associated with host immunity, and affects human health and disease. Therefore, the current progress and trends in this field...

J Clin Med. 2022 Jul 30;11(15):4459. doi: 10.3390/jcm11154459.ABSTRACTBACKGROUND: More and more trials have been conducted. We aimed to assess the efficacy and safety of different JAKinibs in RA.METHODS: A systematic search of randomized controlled trials (RCTs) with JAKinib treatment in RA published in the Medline, Embase, and Cochrane databases up...

Science. 2022 Aug 12;377(6607):eabj6647. doi: 10.1126/science.abj6647. Epub 2022 Aug 12.ABSTRACTPostmeiotic spermatids use a unique strategy to coordinate gene expression with morphological transformation, in which transcription and translation take place at separate developmental stages, but how mRNAs stored as translationally inert messenger ribonucleoproteins...

Scand J Rheumatol. 2022 Aug 10:1-3. doi: 10.1080/03009742.2022.2103937. Online ahead of print.NO ABSTRACTPMID:35946909 | DOI:10.1080/03009742.2022.2103937

Stem Cell Res. 2022 Aug 4;64:102881. doi: 10.1016/j.scr.2022.102881. Online ahead of print.ABSTRACTCHCHD2 mutations have been reported to cause Parkinson's disease (PD) by a loss of function in mitochondria. Most reported mutations, however, were missense, which was not the perfect model for a study of haploinsufficiency. Here, a truncated mutation,...