PNAS - RSS feed of Early Edition articles

Proceedings of the National Academy of Sciences RSS feed -- Early Edition

Latest articles

Niche expansion for phototrophic sulfur bacteria at the Proterozoic-Phanerozoic transition [Earth, Atmospheric, and Planetary Sciences]

Fossilized carotenoid hydrocarbons provide a window into the physiology and biochemistry of ancient microbial phototrophic communities for which only a sparse and incomplete fossil record exists. However, accurate interpretation of carotenoid-derived biomarkers requires detailed knowledge of the carotenoid inventories of contemporary phototrophs and...

Mixed-flow design for microfluidic printing of two-component polymer semiconductor systems [Chemistry]

The rational creation of two-component conjugated polymer systems with high levels of phase purity in each component is challenging but crucial for realizing printed soft-matter electronics. Here, we report a mixed-flow microfluidic printing (MFMP) approach for two-component π-polymer systems that significantly elevates phase purity in bulk-heterojunction...

Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins [Physiology]

Ion channels in excitable cells function in macromolecular complexes in which auxiliary proteins modulate the biophysical properties of the pore-forming subunits. Hyperpolarization-activated, cyclic nucleotide-sensitive HCN4 channels are critical determinants of membrane excitability in cells throughout the body, including thalamocortical neurons and...

Adaptation of plasticity to projected maximum temperatures and across climatically defined bioregions [Evolution]

Resilience to environmental stressors due to climate warming is influenced by local adaptations, including plastic responses. The recent literature has focused on genomic signatures of climatic adaptation, but little is known about how plastic capacity may be influenced by biogeographic and evolutionary processes. We investigate phenotypic plasticity...

Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal [Biochemistry]

Selective packaging of the HIV-1 genome during virus assembly is mediated by interactions between the dimeric 5ʹ-leader of the unspliced viral RNA and the nucleocapsid (NC) domains of a small number of assembling viral Gag polyproteins. Here, we show that the dimeric 5′-leader contains more than two dozen NC binding...

Prototypical pacemaker neurons interact with the resident microbiota [Developmental Biology]

Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident microbiota. However, little is known about the evolutionary origin of...

Mechanistic determinants of effector-independent motor memory encoding [Neuroscience]

Coordinated, purposeful movements learned with one effector generalize to another effector, a finding that has important implications for tool use, sports, performing arts, and rehabilitation. This occurs because the motor memory acquired through learning comprises representations that are effector-independent. Despite knowing this for decades, the...

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19) [Applied Biological Sciences]

A series of epidemiological explorations has suggested a negative association between national bacillus Calmette–Guérin (BCG) vaccination policy and the prevalence and mortality of coronavirus disease 2019 (COVID-19). However, these comparisons are difficult to validate due to broad differences between countries such as socioeconomic status, demographic...

LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication [Neuroscience]

Axon–axon interactions are essential for axon guidance during nervous system wiring. However, it is unknown whether and how the growth cones communicate with each other while sensing and responding to guidance cues. We found that the Parkinson’s disease gene, leucine-rich repeat kinase 2 (LRRK2), has an unexpected role in growth...

The sun of Rome is set! Volcanic dust veils and their political fallout [Commentaries]

Within a year of the slaying of Julius Caesar, Okmok volcano in the Aleutian Islands (Fig. 1) begat one of the greatest eruptions of the past 2,500 y, according to research in PNAS (1). The study explores the repercussions of climatic change induced by the eruption for the unstable Roman...

Discover, share and read the best on the web

Subscribe to RSS Feeds, Blogs, Podcasts, Twitter searches, Facebook pages, even Email Newsletters! Get unfiltered news feeds or filter them to your liking.

Get Inoreader
Inoreader - Subscribe to RSS Feeds, Blogs, Podcasts, Twitter searches, Facebook pages, even Email Newsletters!