Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants [Plant Biology]

Plant and animal intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors detect pathogen-derived molecules and activate defense. Plant NLRs can be divided into several classes based upon their N-terminal signaling domains, including TIR (Toll-like, Interleukin-1 receptor, Resistance protein)- and CC (coiled-coil)-NLRs. Upon ligand...

5d

Correction to Supporting Information for Zadra et al., Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer [SI Correction]

MEDICAL SCIENCES Correction to Supporting Information for “Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer,” by Giorgia Zadra, Caroline F. Ribeiro, Paolo Chetta, Yeung Ho, Stefano Cacciatore, Xueliang Gao, Sudeepa Syamala, Clyde Bango, Cornelia Photopoulos, Ying Huang, Svitlana Tyekucheva,...

5d

Tonoplast-localized Ca2+ pumps regulate Ca2+ signals during pattern-triggered immunity in Arabidopsis thaliana [Plant Biology]

One of the major events of early plant immune responses is a rapid influx of Ca2+ into the cytosol following pathogen recognition. Indeed, changes in cytosolic Ca2+ are recognized as ubiquitous elements of cellular signaling networks and are thought to encode stimulus-specific information in their duration, amplitude, and frequency. Despite...

5d

Correction for Tzafetas et al., The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease [Correction]

MEDICAL SCIENCES, CHEMISTRY Correction for “The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease,” by Menelaos Tzafetas, Anita Mitra, Maria Paraskevaidi, Zsolt Bodai, Ilkka Kalliala, Sarah Bowden, Konstantinos Lathouras, Francesca Rosini, Marcell Szasz, Adele Savage, Julia Balog, James McKenzie,...

5d

Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development [Plant Biology]

Buried seedlings undergo dramatic developmental transitions when they emerge from soil into sunlight. As central transcription factors suppressing light responses, PHYTOCHROME-INTERACTING FACTORs (PIFs) and ETHYLENE-INSENSITIVE 3 (EIN3) actively function in darkness and must be promptly repressed upon light to initiate deetiolation. Microproteins are...

5d

Correction for Pearson et al., Securing timelines in the ancient Mediterranean using multiproxy annual tree-ring data [Correction]

ANTHROPOLOGY, CHEMISTRY Correction for “Securing timelines in the ancient Mediterranean using multiproxy annual tree-ring data,” by Charlotte Pearson, Matthew Salzer, Lukas Wacker, Peter Brewer, Adam Sookdeo, and Peter Kuniholm, which was first published March 30, 2020; 10.1073/pnas.1917445117 (Proc. Natl. Acad. Sci. U.S.A. 117, 8410–8415). The authors...

5d

Light modulates the gravitropic responses through organ-specific PIFs and HY5 regulation of LAZY4 expression in Arabidopsis [Plant Biology]

Light and gravity are two key environmental factors that control plant growth and architecture. However, the molecular basis of the coordination of light and gravity signaling in plants remains obscure. Here, we report that two classes of transcription factors, PHYTOCHROME INTERACTING FACTORS (PIFs) and ELONGATED HYPOCOTYL5 (HY5), can directly bind...

5d

Thermodynamic energetics underlying genomic instability and whole-genome doubling in cancer [Chemistry]

Genomic instability contributes to tumorigenesis through the amplification and deletion of cancer driver genes. DNA copy number (CN) profiling of ensembles of tumors allows a thermodynamic analysis of the profile for each tumor. The free energy of the distribution of CNs is found to be a monotonically increasing function of...

5d

A connectomics approach to understanding a retinal disease [Neuroscience]

Macular telangiectasia type 2 (MacTel), a late-onset macular degeneration, has been linked to a loss in the retina of Müller glial cells and the amino acid serine, synthesized by the Müller cells. The disease is confined mainly to a central retinal region called the MacTel zone. We have used electron...

5d

A mechanism-aware and multiomic machine-learning pipeline characterizes yeast cell growth [Biophysics and Computational Biology]

Metabolic modeling and machine learning are key components in the emerging next generation of systems and synthetic biology tools, targeting the genotype–phenotype–environment relationship. Rather than being used in isolation, it is becoming clear that their value is maximized when they are combined. However, the potential of integrating these two frameworks...

5d