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Proceedings of the National Academy of Sciences current issue

Proceedings of the National Academy of Sciences RSS feed -- current issue

Latest articles

Correction for Sharma et al., Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a [Correction]

IMMUNOLOGY Correction for “Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a,” by Amit Sharma, Manish Kumar, Jyotirmoi Aich, Manoj Hariharan, Samir K. Brahmachari, Anurag Agrawal, and Balaram Ghosh, which was first published March 23, 2009; 10.1073/pnas.0808743106 (Proc. Natl. Acad. Sci. U.S.A. 106, 5761–5766). The authors...

Correction for Pedercini et al., Harvesting synergy from sustainable development goal interactions [Correction]

SUSTAINABILITY SCIENCE Correction for “Harvesting synergy from sustainable development goal interactions,” by Matteo Pedercini, Steve Arquitt, David Collste, and Hans Herren, which was first published October 30, 2019; 10.1073/pnas.1817276116 (Proc. Natl. Acad. Sci. U.S.A. 116, 23021–23028). The authors note that the following statement should be added...

Correction for Namouchi et al., Integrative approach using Yersinia pestis genomes to revisit the historical landscape of plague during the Medieval Period [Correction]

MICROBIOLOGY Correction for “Integrative approach using Yersinia pestis genomes to revisit the historical landscape of plague during the Medieval Period,” by Amine Namouchi, Meriam Guellil, Oliver Kersten, Stephanie Hänsch, Claudio Ottoni, Boris V. Schmid, Elsa Pacciani, Luisa Quaglia, Marco Vermunt, Egil L. Bauer, Michael Derrick, Anne Ø. Jensen, Sacha...

Cognitive and brain development is independently influenced by socioeconomic status and polygenic scores for educational attainment [Psychological and Cognitive Sciences]

Genetic factors and socioeconomic status (SES) inequalities play a large role in educational attainment, and both have been associated with variations in brain structure and cognition. However, genetics and SES are correlated, and no prior study has assessed their neural associations independently. Here we used a polygenic score for educational...

Genomic evidence for convergent evolution of gene clusters for momilactone biosynthesis in land plants [Plant Biology]

Momilactones are bioactive diterpenoids that contribute to plant defense against pathogens and allelopathic interactions between plants. Both cultivated and wild grass species of Oryza and Echinochloa crus-galli (barnyard grass) produce momilactones using a biosynthetic gene cluster (BGC) in their genomes. The bryophyte Calohypnum plumiforme (formerly...

Patterns of sociocognitive stratification and perinatal risk in the child brain [Psychological and Cognitive Sciences]

The expanding behavioral repertoire of the developing brain during childhood and adolescence is shaped by complex brain–environment interactions and flavored by unique life experiences. The transition into young adulthood offers opportunities for adaptation and growth but also increased susceptibility to environmental perturbations, such as the characteristics...

Evaluation of plant sources for antiinfective lead compound discovery by correlating phylogenetic, spatial, and bioactivity data [Pharmacology]

Antibiotic resistance and viral diseases are rising around the world and are becoming major threats to global health, food security, and development. One measure that has been suggested to mitigate this crisis is the development of new antibiotics. Here, we provide a comprehensive evaluation of the phylogenetic and biogeographic patterns...

The {beta}-arrestin-biased {beta}-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility [Pharmacology]

A decrease in skeletal muscle strength and functional exercise capacity due to aging, frailty, and muscle wasting poses major unmet clinical needs. These conditions are associated with numerous adverse clinical outcomes including falls, fractures, and increased hospitalization. Clenbuterol, a β2-adrenergic receptor (β2AR) agonist enhances skeletal muscle...

Spike-induced ordering: Stochastic neural spikes provide immediate adaptability to the sensorimotor system [Systems Biology]

Most biological neurons exhibit stochastic and spiking action potentials. However, the benefits of stochastic spikes versus continuous signals other than noise tolerance and energy efficiency remain largely unknown. In this study, we provide an insight into the potential roles of stochastic spikes, which may be beneficial for producing on-site adaptability...

Chloroplast Sec14-like 1 (CPSFL1) is essential for normal chloroplast development and affects carotenoid accumulation in Chlamydomonas [Plant Biology]

Plastid isoprenoid-derived carotenoids serve essential roles in chloroplast development and photosynthesis. Although nearly all enzymes that participate in the biosynthesis of carotenoids in plants have been identified, the complement of auxiliary proteins that regulate synthesis, transport, sequestration, and degradation of these molecules and their...

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