Observing Hematopoietic Stem Cells Differentiate Into Blood Cells in Living Mouse

Dr. Hans-Reimer RodewaldCredit: DKFZGerman researchers develop a way to equip mouse hematopoietic (blood) stem cells with a fluorescent marker that can be switched on from the outside. Using this tool, they were able to observe, for the first time, how stem cells mature into blood cells under normal conditions in a living organism.In the bone marrow,...

May 2015

Hematopoietic Stem Cell Transplants Work Better than Drugs for Severe Multiple Sclerosis

Demyelination by multiple sclerosis. The CD68 colored tissue shows several macrophages in the area of the lesion. Original scale 1:100New study reveals that hematopoietic stem cell transplants may be more effective than the drug mitoxantrone for people with severe cases of multiple sclerosis.The study appears in the online issue of Neurology®, the medical...

May 2015

Global Stem Cells Announces Alliance with Regenerative Technology Alliance

Global Stem Cells Group announced yesterday that it has signed a memorandum of understanding with the Regenerative Technology Alliance (RTA) to evaluate and promote stem cell training programs.Global Stem Cells Group and the Regenerative Technology Alliance (RTA) have signed a memorandum of understanding to evaluate and promote stem cell training programs.RTA,...

May 2015

Engineers Put the 'Squeeze' on Human Mesenchymal Stem Cells

Inside the cell, calcium ions are released from a structure called the endoplasmic reticulum (ER). Forces applied to the bead cause ion channels in the ER to open mechanically (shown in red above), rather through biochemical signaling chemically (shown in green below). Credit: Jie Sun/Peter Wang research groupBy using optical tweezers to squeeze a tiny...

May 2015

Endothelial Cells Improve the Differentiation of Pluripotent Stem Cells to Blood Cells

Hans-Peter KiemCreditBlood vessel cells improve the conversion of pluripotent stem cells like iPSCs to blood lineages.Hematopoietic stem cells (HSCs) can differentiate into all the kinds of ce ls that comprise the blood and immune cell lineages. For decades now, hematopoietic stem cell transplantation is the only viable option for certain blood disorders,...

May 2015

Study Identifies Stem Cell Signaling Process That Gives Rise to Intestinal Tumors

Location and appearance of two example intestinal tumorsResearchers identify signaling molecules in intestinal stem cells that can give rise to cancer stem cells and tumors if left unregulated. The research suggests a new approach to targeting intestinal cancers.Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) announced today...

May 2015

Creative Medical Health Files Patent on Multiple Sclerosis Mesenchymal Stem Cell Therapy

Creative Medical Health (CMH) announced today that it has filled a patent of intellectual property covering the utilization of its proprietary mesenchymal stem cell-based product for treatment for autoimmune diseases, with multiple sclerosis being the first disease in which the product will be clinically assessed.The patent covers various modifications...

May 2015

Human Embryonic Stem Cells Repair Brain Damage in Rats Caused by Radiation Therapy

Rats treated with the human cells regained cognitive and motor functions that were lost after brain irradiation.Credit: Dr. Denis Soulet, Laval University, QuebecHuman stem cells used successfully to repair brain damage in rats caused by radiation therapy for cancerFor patients with brain cancer, radiation treatment is a powerful and potentially life-saving...

May 2015

Malaria-in-a-Dish Paves the Way for Personalized Treatments

Plasmodium vivax liver-stage infection in iPSC-derived liver cells at eight days after infection. Credit: Ng et al.MIT researchers use induced pluripotent stem cells, to screen potential antimalarial drugs and vaccines for their ability to treat the liver stage of malaria infection. Researchers at the Massachusetts Institute of Technology (MIT) have...

May 2015

Results of Neural Stem Cells for Macular Degeneration to be Presented at Ophthalmology Conference

Picture of the fundus showing intermediate age-related macular degenerationStemCells, Inc. a company developing cell-based therapeutics for disorders of the central nervous system, announced today that it will present the results of its Phase I/II study in dry age related macular degeneration (AMD) at the Angiogenesis, Exudation and Degeneration 2015...

May 2015