Radiotherapy and Oncology

Radiotherapy and Oncology RSS feed. Radiotherapy and Oncology publishes papers describing original research as well as review articles. It covers areas of interest relating to radiation oncology. This includes: clinical radiotherapy, combined modalit

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Low risk of radiation myelopathy with relaxed spinal cord dose constraints in de novo, single fraction spine stereotactic radiosurgery

Spinal metastases cause significant morbidity to patients including severe pain, spinal instability and fracture, and neurologic compromise secondary to malignant epidural spinal cord compression (MESCC).[1] With advances in systemic therapy, patients are surviving longer with metastatic disease.[2–4] As a result, local therapies which offer durable...

Relationships between rectal and perirectal doses and rectal bleeding or tenesmus in pooled voxel-based analysis of 3 randomised phase III trials

Gastrointestinal (GI) symptoms remain a commonly-reported side-effect of prostate external beam radiotherapy (EBRT)[1,2], despite improvements in precision from new technologies such as image guided intensity modulated radiotherapy (IG-IMRT)[3]. Improving the accuracy of predictive toxicity models, through further understanding of the relationship between...

An especially high rate of radiation pneumonitis observed in patients treated with thoracic radiotherapy and simultaneous osimertinib

Osimertinib is a potent, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that has been approved as standard of care for patients with non-small cell lung cancer (NSCLC) harboring EGFR-sensitive or T790M mutations, and approximately 4% of patients develop interstitial pneumonitis (ILD) in response to Osimertinib[1,2]....

Dose dependent cerebellar atrophy in glioma patients after radio(chemo)therapy

Radiotherapy is part of the standard treatment of high-grade gliomas following primary resection [1,2]. In particular, expanded clinical target volumes, but also technical limitations in dose delivery, such as positioning uncertainties and physical properties of the used irradiation technique, inevitably lead to irradiation of surrounding normal appearing...

Effect of baseline sarcopenia on adjuvant treatment for D2 dissected gastric cancer: Analysis of the ARTIST phase III trial

Gastric cancer (GC) remains one of the most prevalent neoplasms worldwide. It is the sixth most common cancer, with an incidence of 1.2 million cases, and the second-leading cause of cancer-related death, with 865,000 deaths in 2017 [1]. The efficacy of adjuvant chemo-radiotherapy (CRT) over surgery alone was proven in the Intergroup 0116 trial [2,3],...

Liver-directed combined radiotherapy as a bridge to curative surgery in locally advanced hepatocellular carcinoma beyond the milan criteria

The standard curative treatment for hepatocellular carcinoma (HCC) is surgical resection or liver transplantation (LT). Most HCC patients are diagnosed as locally advanced[1], thus, rendering the tumor unresectable and untransplantable. Treatment recommendations in the Barcelona Clinic Liver Cancer (BCLC) guidelines are limited to single-modality treatments,...

Changes in gastric anatomy after delivery of breath-hold MR-guided SABR for adrenal metastases

A pooled meta-analysis and systematic review of the outcomes of stereotactic ablative radiotherapy (SABR) for adrenal metastases revealed good 1-year local control rates, and low rates of toxicity [1]. However, the studies included were mostly small, and the retrospective nature of the studies may have led to toxicity being underestimated. High-dose...

The use of hyaluronic acid hydrogel as a tumour bed marker in breast-conserving therapy

Breast-conserving therapy (BCT) is a standard treatment for T1-T2 stage breast cancer [1–4]. Recent studies show that BCT achieves the recurrence rate better than mastectomy[5–9]. It is, however, reliant upon high precision of radiation treatment planning and treatment accuracy. One of the greatest uncertainties in breast radiotherapy is the target...

Reprint of: Practice recommendations for risk-adapted head and neck cancer radiotherapy during the COVID-19 pandemic: An ASTRO-ESTRO consensus statement

Because of the unprecedented disruption of health care services caused by the COVID-19 pandemic, the American Society of Radiation Oncology (ASTRO) and the European Society for Radiotherapy and Oncology (ESTRO) identified an urgent need to issue practice recommendations for radiation oncologists treating head and neck cancer (HNC) in a time of limited...

Interpreting clinical significance of machine learning approaches and radiomics in radiation oncology trials

We applaud the effort by Yang et al in attempting to harness machine learning approach to predict lymph node (LN) metastasis in gastric cancer [1]. As the number of research using machine learning solutions to oncological problems increases, clinicians need to be able to appraise such research with systematic methodology to interpret clinical significance...

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