The Lancet

The Lancet RSS feed. The Lancet is the world's leading independent general medical journal. The journal's coverage is international in focus and extends to all aspects of human health. The Lancet publishes the original primary research and review art

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[Comment] Planetary health and the 2020 US election

Elections impact health through changes in both health-care delivery1 and upstream social and environmental policies. The upcoming US election presents stark contrasts in environmental policies that will affect health in the USA and globally. Here we examine these contrasts through the lens of planetary health.2

[Comment] Confronting antimicrobial resistance beyond the COVID-19 pandemic and the 2020 US election

Globally, the USA has recorded the highest number of COVID-19 cases and deaths,1 and still needs to simultaneously respond to another looming potential pandemic. The rise in multidrug-resistant bacterial infections that are undetected, undiagnosed, and increasingly untreatable threatens the health of people in the USA and globally. In 2020 and beyond,...

[Correspondence] Lockdown impact on COVID-19 epidemics in regions across metropolitan France

Lockdowns have been used by most European countries in response to the COVID-19 pandemic. In France, a national lockdown was implemented on March 17, 2020. Some have questioned the need for a nationwide implementation given that most hospital admissions were concentrated in two of 13 regions; others have even questioned the impact of the lockdown on...

[Articles] Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial

These initial results do not support routine administration of adjuvant radiotherapy after radical prostatectomy. Adjuvant radiotherapy increases the risk of urinary morbidity. An observation policy with salvage radiotherapy for PSA biochemical progression should be the current standard after radical prostatectomy.

[Comment] Timing of radiotherapy after radical prostatectomy

The optimal timing of radiotherapy after radical prostatectomy remains unclear. Previous prospective, randomised clinical trials showing that adjuvant radiotherapy was associated with a reduced risk of recurrence in patients at risk (ie, positive surgical margins, pathological T-stage 3 (pT3) disease, Gleason score 8–10) were confounded by either late...

[Correspondence] An open letter to Japan's new Prime Minister

On Sept 16, 2020, Yoshihide Suga was inaugurated as Japan's new Prime Minister after the resignation of former Prime Minister Shinzo Abe. One of Abe's political legacies was Japan's commitment to global health.1 Abe has been the leading advocate for human security and universal health coverage. Under his leadership, Japan contributed to revamping global...

[Articles] Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data

This collaborative and prospectively designed systematic review and meta-analysis suggests that adjuvant radiotherapy does not improve event-free survival in men with localised or locally advanced prostate cancer. Until data on long-term outcomes are available, early salvage treatment would seem the preferable treatment policy as it offers the opportunity...

[Articles] Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry

In patients with COVID-19 who received ECMO, both estimated mortality 90 days after ECMO and mortality in those with a final disposition of death or discharge were less than 40%. These data from 213 hospitals worldwide provide a generalisable estimate of ECMO mortality in the setting of COVID-19.

[Articles] Prevalence of SARS-CoV-2 antibodies in a large nationwide sample of patients on dialysis in the USA: a cross-sectional study

During the first wave of the COVID-19 pandemic, fewer than 10% of the US adult population formed antibodies against SARS-CoV-2, and fewer than 10% of those with antibodies were diagnosed. Public health efforts to limit SARS-CoV-2 spread need to especially target racial and ethnic minority and densely populated communities.

[Comment] SARS-CoV-2 antibody seroprevalence in patients receiving dialysis in the USA

Antibody serosurveillance is an essential tool for monitoring the COVID-19 pandemic, offering a more comprehensive picture of who has been infected than swab testing of symptomatic individuals alone. In recent months, several countries have done large-scale seroprevalence surveys, including the USA,1,2 China,3 Brazil,4 England,5 and Spain.6 These studies...

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