AbstractBackgroundEvidence about the clinical impact of rapid diagnostic tests (RDT) for the diagnosis of bloodstream infections is limited, and whether RDT are superior to conventional blood cultures (BC) embedded within antimicrobial stewardship programs (ASP) is unknown.MethodsWe performed network meta-analyses (NMA) using results from studies of...

An error appeared in the 15 October 2023 issue of the journal (McCreary et al. “Antibiotic Myths for the Infectious Diseases Clinician.” Clin Infect Dis 77(8): 1120–1125. https://doi.org/10.1093/cid/ciad357). The article contains the statement: “However, clinical studies, including a randomized controlled trial by Cosgrove et al, did not demonstrate...

AbstractThis study describes the largest cohort to date (n=147) of pregnant patients living with HIV on bictegravir (BIC). BIC in pregnancy was associated with high levels of viral suppression and similar perinatal outcomes to published literature. These findings support consideration for use of BIC in management of HIV during pregnancy.

AbstractBackgroundPre-transplant respiratory virus (RV) infections have been associated with negative transplant outcomes in adult hematopoietic cell transplantation (HCT) recipients. In the era of HCT delay due to high-risk RVs, we examined the impact of pre-transplant RV detection on transplant outcomes in a pediatric HCT recipients.MethodsThis retrospective...

AbstractIn a multi-hospital cohort study of 3392 patients, positive urinalysis parameters had poor positive predictive value for diagnosing urinary tract infection (UTI). Combined urinalysis parameters (pyuria or nitrite) performed better than pyuria alone for ruling out UTI. However, performance of all urinalysis parameters was poor in older women.

AbstractMedical historians typically situate the origins of the antimicrobial era during the early germ period at the turn of the 20th century. They have regarded the development of chemical compounds designed to treat infectious diseases by killing their causative germ as the beginning of the antimicrobial era. Scholars, however, had been speculating...