In the Pipeline

Derek Lowe’s commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.

Latest articles

Monoclonal Antibody Data

We have a bit of human clinical data from the Eli Lilly/Abcellera collaboration to make a monoclonal antibody therapy against the coronavirus. A full paper is coming soon, the press release says, but for now it looks like this is all we have to go on. It’s a mixed assortment of news. On the cheerful side, in mild-to-moderate recently diagnosed...

Phosphine, Life, and Venus

Well, as a chemist – one who does amateur astronomy on the side, yet – it’s obligatory that I write about the phosphine on Venus paper that came out yesterday. This one’s embargo was spectacularly leaky, so everyone who’s really into this stuff had various kinds of advance warning, but the news certainly has made a splash. So what’s phosphine?...

Vaccine Transparency

I’ve been emphasizing for some time that our efforts to find and deploy a coronavirus vaccine have to be as transparent as possible to increase the chances for success. Recent events make that more clear than ever – and not in a good way. Update: Moderna has now published their complete clinical trial protocol, and good for them. Where are the...

Drug Repurposing: How Often Does It Work?

Here’s an article that will not be popular among some constituencies. It’s in a special issue of the Journal of Chemical Information and Modeling, devoted to how these disciplines have responded to the coronavirus pandemic. And in it, Aled Edwards of the Structural Genomics Consortium surveys past attempts at drug repurposing and arrives at a conclusion...

The Russian Vaccine Data

An open letter has appeared about the recently published data from the vaccine development effort at Russia’s Gamaleya reseach center. This is of course the one that the government announced had been “approved” before even going through any Phase III trials, an even that I characterized at the time as a “ridiculous publicity stunt” (a description that...

Serious Adverse Event Time

Lots of uncertainty in the vaccine world today: as many will have heard, the Oxford/AstraZeneca trial in the UK, the US, and Brazil has been paused due to a serious adverse event. The New York Times, citing a source with knowledge of the event, reported last night that this was transverse myelitis. And Nature has noted that the volunteer information...

Bradykinin and the Coronavirus

There’s a new paper that a lot of people are talking about recently that presents a rather large unifying hypothesis about the effects of the coronavirus (and suggests some new modes of treatment as well). This is the “bradykinin hypothesis”, and before digging into it, it might be worth a paragraph to talk about what bradykinin is. It’s a 9-amino-acid...

Coronavirus Vaccine Roundup, Early September

It’s been a while since I went through the whole vaccine landscape (I’ve been putting it off!), but there’s a lot to catch up on. I’m going to incorporate some slightly reworked material from my July post in the introduction to each vaccine class, for reference, but everything on the candidates themselves is updated information. That earlier post includes...

It’s Weird Down There

It’s not easy – especially when you’re a mere chemist – to picture what’s really going on inside a cell. The sorts of pictures that most of us tend to use (two blobs to represent a ribosome, little snakey line curving out from it to represent a new protein) are helpful memory devices, but have very little to do with reality. Just to pick one example,...

Cold Chain (And Colder Chain) Distribution

OK, it looks like we’re finally going to be talking about a vaccine logistics issue that many people (including me) have been worried about. Specifically, how are these things going to be transported and stored? If you’re not in the biomedical field, that question might seem a bit boring and bring up mental pictures of 18-wheel trucks and forklifts...

Discover, share and read the best on the web

Subscribe to RSS Feeds, Blogs, Podcasts, Twitter searches, Facebook pages, even Email Newsletters! Get unfiltered news feeds or filter them to your liking.

Get Inoreader
Inoreader - Subscribe to RSS Feeds, Blogs, Podcasts, Twitter searches, Facebook pages, even Email Newsletters!