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Predicting personality from patterns of behavior collected with smartphones [Psychological and Cognitive Sciences]

Smartphones enjoy high adoption rates around the globe. Rarely more than an arm’s length away, these sensor-rich devices can easily be repurposed to collect rich and extensive records of their users’ behaviors (e.g., location, communication, media consumption), posing serious threats to individual privacy. Here we examine the extent to which...<img...

Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti-HIV-1 IgG1 antibodies in vivo [Microbiology]

In combating viral infections, the Fab portion of an antibody could mediate virus neutralization, whereas Fc engagement of Fc-γ receptors (FcγRs) could mediate an array of effector functions. Evidence abounds that effector functions are important in controlling infections by influenza, Ebola, or HIV-1 in animal models. However, the relative contribution...<img...

Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function [Applied Biological Sciences]

Erythrocytes naturally capture certain bacterial pathogens in circulation, kill them through oxidative stress, and present them to the antigen-presenting cells (APCs) in the spleen. By leveraging this innate immune function of erythrocytes, we developed erythrocyte-driven immune targeting (EDIT), which presents nanoparticles from the surface of erythrocytes...

Type I IFN is siloed in endosomes [Immunology and Inflammation]

Type I IFN (IFN-I) is thought to be rapidly internalized and degraded following binding to its receptor and initiation of signaling. However, many studies report the persistent effects mediated by IFN-I for days or even weeks, both ex vivo and in vivo. These long-lasting effects are attributed to downstream signaling...<img src="http://feeds.feedburner.com/~r/Pnas-RssFeedOfEarlyEditionArticles/~4/ar4-BikMaro"...

Ranking essential bacterial processes by speed of mutant death [Microbiology]

Mutant phenotype analysis of bacteria has been revolutionized by genome-scale screening procedures, but essential genes have been left out of such studies because mutants are missing from the libraries analyzed. Since essential genes control the most fundamental processes of bacterial life, this is a glaring deficiency. To address this limitation,...<img...

Behavioral tagging underlies memory reconsolidation [Neuroscience]

Memory reconsolidation occurs when a retrieving event destabilizes transiently a consolidated memory, triggering thereby a new process of restabilization that ensures memory persistence. Although this phenomenon has received wide attention, the effect of new information cooccurring with the reconsolidation process has been less explored. Here we demonstrate...

Fetal public V{gamma}9V{delta}2 T cells expand and gain potent cytotoxic functions early after birth [Immunology and Inflammation]

Vγ9Vδ2 T cells are a major human blood γδ T cell population that respond in a T cell receptor (TCR)-dependent manner to phosphoantigens which are generated by a variety of microorganisms. It is not clear how Vγ9Vδ2 T cells react toward the sudden microbial exposure early after birth. We found...<img src="http://feeds.feedburner.com/~r/Pnas-RssFeedOfEarlyEditionArticles/~4/6RGSd3KZdUg"...

Phase imaging of transition from classical to quantum plasmonic couplings between a metal nanoparticle and a metal surface [Chemistry]

When a metal nanoparticle is brought near to a metal surface within electron tunneling distance (∼1 nm), classical electromagnetic coupling between the nanoparticle and the metal is expected to transition to quantum coupling. We show that this transition can be observed as a drastic phase change in the surface plasmon...<img src="http://feeds.feedburner.com/~r/Pnas-RssFeedOfEarlyEditionArticles/~4/Vs6UXPxYm94"...

Behavioral tagging underlies memory reconsolidation [Neuroscience]

Memory reconsolidation occurs when a retrieving event destabilizes transiently a consolidated memory, triggering thereby a new process of restabilization that ensures memory persistence. Although this phenomenon has received wide attention, the effect of new information cooccurring with the reconsolidation process has been less explored. Here we demonstrate...

Predicting personality from patterns of behavior collected with smartphones [Psychological and Cognitive Sciences]

Smartphones enjoy high adoption rates around the globe. Rarely more than an arm’s length away, these sensor-rich devices can easily be repurposed to collect rich and extensive records of their users’ behaviors (e.g., location, communication, media consumption), posing serious threats to individual privacy. Here we examine the extent to which...

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