Polyfunctionalized arenes are prevalent compounds in pharmaceuticals, natural products, and organic molecules. Therefore, the quest for innovative synthetic routes to get access to these multisubstituted compounds in an efficient and straightforward manner is of paramount importance. From the palladium/norbornene-catalyzed ipso/ortho difunctionalization...

Transition metal-catalyzed cross-couplings are reliable for linking aryl electrophiles and nucleophiles, creating diverse aromatic compounds. Aromatic ketones, typically intermediates, are seldom used as electrophiles due to the difficulty of cleaving strong C–C bonds. We introduce a method utilizing aromatic ketones as electrophiles, transforming them...

The industrial Haber-Bosch process, a cornerstone in converting atmospheric nitrogen (N2) to metabolic ammonia (NH3), is marked by its significant carbon footprint. With the widespread deployment of renewable energy systems, exploring sustainable approaches for ambient, low-carbon, and decentralized NH3 production is promising yet challenging. This...

The concept of “hard and soft electrons and holes” introduces a criterion for rationalizing the regioselectivity in chemical reactions. Shortcomings of existing models are bypassed by utilizing the responses of the electronic shell to the fine-grained different behavior of single and paired electrons. Straightforward electronic considerations, which...

This study discloses the borane-catalyzed synthesis of organochalcogenides using readily available arenes, heteroarenes, and pharmacophores, and the installation of the industrially relevant trifluoromethylthio group, in high yields. Furthermore, the protocol enables the late-stage selective chalcogenation of drug derivatives such as naproxen and estradiol...

Absorption of a significant part of the solar spectrum requires multichromophoric systems that collect and funnel the energy to a central unit. Different from previous designs, we herein introduce a foldamer composed of four different dipolar merocyanine dyes that form a tightly stacked H-aggregate, thereby creating a set of exciton states for panchromatic...