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Nature Biotechnology - Issue - nature.com science feeds

Nature Biotechnology journal featuring biotechnology articles and science research papers of commercial interest in pharmaceutical, medical, and environmental sciences.
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A community effort to optimize sequence-based deep learning models of gene regulation

Nature Biotechnology, Published online: 11 October 2024; doi:10.1038/s41587-024-02414-wA benchmarking competition improves tools that predict how regulatory regions control gene expression.

Fri Oct 11, 2024 13:21
A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy

Nature Biotechnology, Published online: 11 October 2024; doi:10.1038/s41587-024-02420-yThe neoantigen discovery pipeline NeoDisc incorporates mass spectrometry immunopeptidomics data.

Fri Oct 11, 2024 13:21
Model-directed generation of artificial CRISPR–Cas13a guide RNA sequences improves nucleic acid detection

Nature Biotechnology, Published online: 11 October 2024; doi:10.1038/s41587-024-02422-wModel-directed generative design is applied to CRISPR–Cas13a guide RNAs, outperforming natural sequences.

Fri Oct 11, 2024 13:21
An antigen discovery pipeline integrates multi-omics data and informs immunotherapy

Nature Biotechnology, Published online: 11 October 2024; doi:10.1038/s41587-024-02427-5We developed NeoDisc, a computational antigen discovery pipeline that integrates multi-omics data, including genomics, transcriptomics and mass spectrometry-based immunopeptidomics. NeoDisc accurately identifies and prioritizes tumor-specific antigens and designs...

Fri Oct 11, 2024 13:21
A circularly permuted CasRx platform for efficient, site-specific RNA editing

Nature Biotechnology, Published online: 09 October 2024; doi:10.1038/s41587-024-02430-wSite-specific and efficient RNA editing is achieved with a CasRx editor.

Wed Oct 9, 2024 14:21
One-step nanoscale expansion microscopy reveals individual protein shapes

Nature Biotechnology, Published online: 09 October 2024; doi:10.1038/s41587-024-02431-9Combining expansion microscopy with super-resolution radial fluctuations captures the morphology of single proteins.

Wed Oct 9, 2024 14:21

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