Nature Reviews Molecular Cell Biology, Published online: 02 May 2024; doi:10.1038/s41580-024-00741-zStephanie Moon discusses findings that revealed that ribosome stalling can lead to the suppression of translation initiation in the brain, delaying the onset of neurodegeneration.

Nature Reviews Molecular Cell Biology, Published online: 02 May 2024; doi:10.1038/s41580-024-00740-0Claire Durrant reminds us of the importance of studying the physiological roles of proteins and their aggregates to understand their roles in disease and inform therapies, discussing a 2008 paper on amyloid-β from the Arancio lab.

Nature Reviews Molecular Cell Biology, Published online: 30 April 2024; doi:10.1038/s41580-024-00730-2Oxidation–reduction (redox) reactions involving reactive oxygen, nitrogen and sulfur species are vital for life, but excessive oxidant levels contribute to ageing and diseases. This Review explores cellular dynamics of redox homeostasis, such as responses...

Nature Reviews Molecular Cell Biology, Published online: 29 April 2024; doi:10.1038/s41580-024-00733-zDuring embryonic epithelial–mesenchymal transition, epithelial cells undergo substantial phenotypic changes and acquire migration capacity. This Review compares embryonic and adult non-cancer EMTs and discusses the role of EMTs in adult tissue repair...

Nature Reviews Molecular Cell Biology, Published online: 29 April 2024; doi:10.1038/s41580-024-00729-9This article reviews the current landscape of targeted protein degradation approaches and how they have parallels in biological processes. The authors also outline the ongoing clinical exploration of novel degraders and provide some perspectives on...

Nature Reviews Molecular Cell Biology, Published online: 23 April 2024; doi:10.1038/s41580-024-00727-xThe senescence-associated secretory phenotype (SASP) mediates the tissue effects of senescent cells. This Review discusses the composition, regulation and various biological implications of the SASP and its uses as a biomarker and a target of senomorphic...