Nature Chemical Biology, Published online: 06 May 2024; doi:10.1038/s41589-024-01610-8We present a discovery pipeline integrating chemical fragment screening and time-resolved, high-throughput small-angle X-ray scattering (TR-HT-SAXS). This approach identifies allosteric chemical leads targeting distinct allosteric states of the mitochondrial oxidoreductase...

Nature Chemical Biology, Published online: 03 May 2024; doi:10.1038/s41589-024-01593-6CRISPR–Cas13 systems use single-subunit RNA-guided Cas13 effectors for targeted RNA recognition and cleavage. This Review summarizes the recent advances in understanding the structural and mechanistic aspects of Cas13 systems and the diverse applications of these systems...

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01615-3Engineering from evolution

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01616-2Bacteria lose a pep in their step

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01617-1Setting the pace for degrons

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01609-1A discovery pipeline integrating time-resolved HT-SAXS and fragment screening identifies chemical leads targeting exemplary allosteric states of mitochondrial oxidoreductase apoptosis-inducing factor (AIF).