A method is reported to modify the backbone chemistry of PEG-based bottlebrush polymers using heterobifunctional norbornene macromonomers. Furthermore, it is shown that the biological fate of micellar nanoparticles with PEG-bottlebrush shell is affected by the backbone chemistry while achieving long systemic circulation in mice. Abstract Nanoparticle...

Curcumin, a natural origin compound, is increasingly gaining prominence in the scientific community for its various benefits for human health, being considered a hope for many patients. Therefore, this review seeks to update and compile important points, from its cultivation to human application, including its association with nanotechnology, an important...

Abstract Infected diabetic wound (DW) presents a prolonged and challenging healing process within the field of regenerative medicine. The effectiveness of conventional drug therapies is hindered by their limited ability to reach deep tissues and promote adequate wound healing rates. Therefore, there is an imperative to develop drug delivery systems...

Abstract Accumulating evidence highlights p38 as a crucial factor highly activated during the process of acute kidney injury (AKI), but the application of p38 inhibitor in AKI was quite limited due to the low efficiency and poor kidney-targeting ability. Herein, a novel self-assembling peptide nanoparticle with specific p38-inhibiting activity was...

Abstract The advent of closed loop bionics has created a demand for electrode materials that are ideal for both stimulating and recording applications. The growing complexity and diminishing size of implantable devices for neural interfaces have moved beyond what can be achieved with conventional metallic electrode materials. Polymeric electrode materials...

An “all in one” acceptor–donor–acceptor fused-ring photosensitizer (Y6-Th) with both bright second near-infrared window (NIR-II) emission with high quantum yield (1.9%), exclusive O2 •−-generating ability, and excellent photothermal therapy performance (photothermal conversion efficiency of 75.8%) is designed for type-I photothermal/photodynamic...