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Neuroendocrine Circuits Governing Energy Balance and Stress Regulation: Functional Overlap and Therapeutic Implications

Yvonne M. Ulrich-Lai, Karen K. Ryan. Significant comorbidities between obesity-related metabolic disease and stress-related psychological disorders suggest important functional interactions between energy balance and brain stress int....

Fri Mar 14, 2014 00:05
Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure

Shaun F. Morrison, Christopher J. Madden, Domenico Tupone. Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic function of brown adipose tissue (BAT) and contributes to the maintenance of body temperature during co....

Fri Mar 14, 2014 00:05
Circuits Controlling Energy Balance and Mood: Inherently Intertwined or Just Complicated Intersections?

Chen Liu, Syann Lee, Joel K. Elmquist. Recent reports of adverse psychiatric events from seemingly different types of weight loss therapies highlight a previously underestimated overlap between CNS circuits that control energy balance ....

Fri Mar 14, 2014 00:05
Cochaperone Binding to LYR Motifs Confers Specificity of Iron Sulfur Cluster Delivery

Nunziata Maio, Anamika Singh, Helge Uhrigshardt, Neetu Saxena, Wing-Hang Tong, Tracey A. Rouault. Iron sulfur (Fe-S) clusters, preassembled on the ISCU scaffold, are transferred to target proteins or to intermediate scaffolds by a dedicated chaperone-cochaperone system. However, the molecular ....

Wed Mar 5, 2014 06:15
Independent Control of Aging and Axon Regeneration

Stephane Belin, Michael Norsworthy, Zhigang He. Axon regeneration capacity often declines with age. One might assume that loss of regeneration is an obvious consequence of organismal aging. However, in the latest issue of Neuron, Byrne e....

Wed Mar 5, 2014 06:15
The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

Samantha M. Solon-Biet, Aisling C. McMahon, J. William O. Ballard, Kari Ruohonen, Lindsay E. Wu, Victoria C. Cogger, Alessandra Warren, Xin Huang, Nicolas Pichaud, Richard G. Melvin, Rahul Gokarn, Mamdouh Khalil, Nigel Turner, Gregory J. Cooney, David A. Sinclair, David Raubenheimer, David G. Le Couteur, Stephen J. Simpson. The fundamental questions...

Wed Mar 5, 2014 06:15

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