Nature Reviews Neurology, Published online: 20 May 2024; doi:10.1038/s41582-024-00961-zIn this Perspective, the authors propose a new classification system for amyotrophic lateral sclerosis and related neurodegenerative disorders that recognizes, in parallel, the clinical syndromes and the underlying biology of disease. The framework emerged from discussions...

Nature Reviews Neurology, Published online: 17 May 2024; doi:10.1038/s41582-024-00967-7Gliomas are the most common malignant primary brain tumours in adults, and they frequently contain mutations in the isocitrate dehydrogenase 1 (IDH1) or IDH2 gene. Small-molecule inhibitors of mutant IDH are emerging as a new therapeutic strategy for IDH-mutant cancers,...

Nature Reviews Neurology, Published online: 16 May 2024; doi:10.1038/s41582-024-00966-8Nociplastic pain arises from altered nociception despite the absence of tissue damage. In this Review, the authors summarize the risk factors and clinical presentation of nociplastic pain, and discuss its potential underlying mechanisms, including evidence of CNS,...

Nature Reviews Neurology, Published online: 14 May 2024; doi:10.1038/s41582-024-00970-yBlood test for early Parkinson disease diagnosis

Nature Reviews Neurology, Published online: 14 May 2024; doi:10.1038/s41582-024-00971-xNanoprobe for blood–brain barrier changes

Nature Reviews Neurology, Published online: 14 May 2024; doi:10.1038/s41582-024-00968-6Genetic protection against Alzheimer disease