Nature Neuroscience, Published online: 13 May 2024; doi:10.1038/s41593-024-01643-1Physiologically relevant stimulation of dopamine neurons does not function as a reward and does not endow cues with a reward representation. However, high-frequency stimulation is represented as a sensory-specific goal that motivates behavior.

Nature Neuroscience, Published online: 13 May 2024; doi:10.1038/s41593-024-01639-xThe subcommissural organ (SCO) is a gland in the brain, and relatively little is known about its function. Zhang et al. genetically ablated SCO cells and observed severe hydrocephalus and neuronal defects. The reintroduction of SCO-derived peptides into SCO-ablated brain...

Nature Neuroscience, Published online: 13 May 2024; doi:10.1038/s41593-024-01638-yIt has been widely believed that a key function of sleep is to actively clear metabolites and toxins from the brain. Miao, Luo et al. show in mice that brain clearance is markedly reduced—not increased—during sleep and anesthesia.

Nature Neuroscience, Published online: 09 May 2024; doi:10.1038/s41593-024-01655-xA neuronally balanced diet

Nature Neuroscience, Published online: 09 May 2024; doi:10.1038/s41593-024-01656-wIncluding tau inclusions

Nature Neuroscience, Published online: 09 May 2024; doi:10.1038/s41593-024-01657-9Big data for everyone