Nature Catalysis brings together researchers from across all chemistry and related fields. It publishes work on homogeneous catalysis, heterogeneous catalysis, and biocatalysts, incorporating both fundamental and applied studies. Nature Catalysis pro
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Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase

Nature Catalysis, Published online: 23 February 2024; doi:10.1038/s41929-024-01117-4The reasons for epistasis, wherein mutations interact non-additively, are often not fully understood. Now it is found that shifting the rate-limiting step from substrate binding to the chemical reaction step during the directed evolution of β-lactamase correlates with...

Fri Feb 23, 2024 17:56
Nickel-electrocatalysed C(<i>sp</i><sup>3</sup>)–C(<i>sp</i><sup>3</sup>) cross-coupling of unactivated alkyl halides

Nature Catalysis, Published online: 23 February 2024; doi:10.1038/s41929-024-01118-3Electrochemical cross-electrophile coupling with alkyl halides for the construction of C(sp3)–C(sp3) bonds is generally limited to activated alkyl halides. Now this approach is extended to coupling of unactivated alkyl halides using a nickel catalyst under mild conditions.

Fri Feb 23, 2024 17:56
A family of di-glutamate mucin-degrading enzymes that bridges glycan hydrolases and peptidases

Nature Catalysis, Published online: 23 February 2024; doi:10.1038/s41929-024-01116-5Mucins are glycosylated proteins with important biological functions such as protection. Although glycopeptidases can cleave them, dedicated hydrolytic enzymes specific for mucins were unknown. Now microbial mucinases are discovered that specifically recognize mucin...

Fri Feb 23, 2024 17:56
Congested C(<i>sp</i><sup>3</sup>)-rich architectures enabled by iron-catalysed conjunctive alkylation

Nature Catalysis, Published online: 23 February 2024; doi:10.1038/s41929-024-01113-8Catalytic conjunctive cross-coupling for the generation of densely functionalized sp3-rich scaffolds that are often found in biologically active compounds is underdeveloped. Now, iron-catalysed dicarbofunctionalization of olefins with dialkylzinc and haloalkanes provides...

Fri Feb 23, 2024 17:56
Visible light-mediated intermolecular crossed [2+2] cycloadditions using a MOF-supported copper triplet photosensitizer

Nature Catalysis, Published online: 23 February 2024; doi:10.1038/s41929-024-01112-9[Cu(phen)(binap)]+ features a relatively high photocatalytic activity, but its low photostability hinders its use in organic chemistry. Now immobilization of this motif on a metal–organic framework matrix enhances its stability and excited-state lifetime, enabling the...

Fri Feb 23, 2024 17:56
Light-induced Pd catalyst enables C(<i>sp</i><sup>2</sup>)–C(<i>sp</i><sup>2</sup>) cross-electrophile coupling bypassing the demand for transmetalation

Nature Catalysis, Published online: 20 February 2024; doi:10.1038/s41929-024-01109-4The direct cross-electrophile coupling of (hetero)aryl halides and pseudohalides is challenging. Now this reaction is facilitated by a visible light-induced palladium catalytic system that differentiates the reactants on the basis of the bond dissociation enthalpy affording...

Tue Feb 20, 2024 14:50

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