Engineered Cas13 variants with minimal collateral RNA targeting

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Engineered Cas13 variants with minimal collateral RNA targeting

Nature Biotechnology, Published online: 12 August 2022; doi:10.1038/s41587-022-01423-xThe application of CRISPR–Cas13 for targeted RNA degradation is hindered by the existence of collateral effects induced by Cas13. We screened hundreds of engineered Cas13 variants using a convenient and sensitive reporter system and obtained several variants with markedly...

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Abalos Therapeutics---arenaviruses take on cancer

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Abalos Therapeutics---arenaviruses take on cancer

Nature Biotechnology, Published online: 12 August 2022; doi:10.1038/d41587-022-00007-zAfter >20 years of research at the intersection of virology and immunology, two brothers have launched a venture seeking to turn arenaviruses into an anticancer virotherapy.

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High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Nature Biotechnology, Published online: 11 August 2022; doi:10.1038/s41587-022-01419-7Several engineered Cas13 variants achieve targeted RNA degradation with minimal collateral effects.

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Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts

Nature Biotechnology, Published online: 11 August 2022; doi:10.1038/s41587-022-01408-wA bioengineered cornea made of collagen restores vision in a pilot clinical study.

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Accessible bioengineered corneal tissue to address a blinding disease globally

Nature Biotechnology, Published online: 11 August 2022; doi:10.1038/s41587-022-01409-9Porcine dermal collagen was chemically and photochemically bioengineered into an implantable tissue mimicking the human corneal extracellular matrix. The implant presents a simpler and safer method than donor cornea transplantation while delivering equivalent outcomes,...

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Accessible bioengineered corneal tissue to address a blinding disease globally

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High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

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Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts

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