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Nature Biotechnology journal featuring biotechnology articles and science research papers of commercial interest in pharmaceutical, medical, and environmental sciences.

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Engineered Cas13 variants with minimal collateral RNA targeting

Engineered Cas13 variants with minimal collateral RNA targeting

Nature Biotechnology, Published online: 12 August 2022; doi:10.1038/s41587-022-01423-xThe application of CRISPR–Cas13 for targeted RNA degradation is hindered by the existence of collateral effects induced by Cas13. We screened hundreds of engineered Cas13 variants using a convenient and sensitive reporter system and obtained several variants with markedly...

Abalos Therapeutics---arenaviruses take on cancer

Abalos Therapeutics---arenaviruses take on cancer

Nature Biotechnology, Published online: 12 August 2022; doi:10.1038/d41587-022-00007-zAfter >20 years of research at the intersection of virology and immunology, two brothers have launched a venture seeking to turn arenaviruses into an anticancer virotherapy.

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Nature Biotechnology, Published online: 11 August 2022; doi:10.1038/s41587-022-01419-7Several engineered Cas13 variants achieve targeted RNA degradation with minimal collateral effects.

Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts

Nature Biotechnology, Published online: 11 August 2022; doi:10.1038/s41587-022-01408-wA bioengineered cornea made of collagen restores vision in a pilot clinical study.

Accessible bioengineered corneal tissue to address a blinding disease globally

Nature Biotechnology, Published online: 11 August 2022; doi:10.1038/s41587-022-01409-9Porcine dermal collagen was chemically and photochemically bioengineered into an implantable tissue mimicking the human corneal extracellular matrix. The implant presents a simpler and safer method than donor cornea transplantation while delivering equivalent outcomes,...

Accessible bioengineered corneal tissue to address a blinding disease globally

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts

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