AbstractDespite significant biomedical advancements in various realms of oncology, the benefits of these developments are not equitably distributed, particularly in under-resourced settings. While much work has described the challenges and systemic barriers in global cancer control, in this essay we focus on success stories. This piece describes clinical...

AbstractIntroductionWhile contact days—days with healthcare contact outside home—are increasingly adopted as a measure of time toxicity and treatment burden, they could also serve as a surrogate of treatment-related harm. We sought to assess the association between contact days and patient-reported outcomes, and the prognostic ability of contact days.MethodsWe...

AbstractBackgroundWe aimed to identify plasma and urinary metabolites related to colorectal cancer (CRC) risk and elucidate their mediator role in the associations between modifiable risk factors and CRC.MethodsMetabolite quantitative trait loci were derived from two published metabolomics genome-wide association studies (GWASs), and summary-level data...

Intramural Research Program of the Division of Cancer Epidemiology and GeneticsNational Cancer Institute10.13039/100000054

AbstractBackgroundThe prognostic value of traditional clinical indicators for locally recurrent nasopharyngeal carcinoma (lrNPC) is limited due to their inability to reflect intratumor heterogeneity. We aimed to develop a radiomic signature to reveal tumor immune heterogeneity and predict survival in lrNPC.MethodsThis multicenter, retrospective study...