B cells stimulated with anti-Ig (B-cell receptor), CpG-C (TLR9), and IFN-g upregulate CD19, CD11c, T-bet, and FcRL5, produce IL6 and IL10, support CD4+ T-cell division and differentiate to plasma cells. CpG-C drives CD19 upregulation, IL10-production and plasma cell differentiation, but not T-cell help. IFN-g drives optimal T-bet expression, but not...

Seventy-seven patients with antiphospholipid syndrome were tested for autoantibodies against C1q, C3, FB, FH, and C4bp. Fifty-seven patients had at least one anti-complement antibody. IgM anti-FH positivity was associated with thrombosis when anti-C3 and anti-FB were, negatively or positively, associated with various noncriteria manifestations of...

In patients with hepatitis C cirrhosis who are treated with 2G DAA, predicted weak NK-cell-mediated immunity may predispose to HCC development more than predicted intermediate or strong NK-cell-mediated immunity. Background and aims Second-generation direct-acting antivirals (2G DAA) to cure HCV have led to dramatic clinical improvements....

European Journal of Immunology, EarlyView.

In the healthy state condition, T-cell maturation occurs in the thymus leading to the exit of matured T cells in the periphery. In infected mice, SARS-CoV-2 infection of the thymocytes results in increased apoptosis of thymocytes which leads to thymic atrophy, and loss of peripheral TCR repertoire. Abstract Pathogenic infections cause thymic...

IL-10 and IL-17 exhibited diverse impacts on regulating MDSCs and airway inflammation. In vitro, IL-10 deficiency increased polymorphonuclear (PMN)-MDSC numbers without affecting their suppressive activity in bone marrow, lung, and spleen. In the asthma model, IL-17 deficiency decreased monocytic (M)-MDSC numbers and suppressive activity in the lung...