Wiley Online Library : Advanced Synthesis & Catalysis
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Copper‐Catalyzed α‐Indolmethylation of 2‐Pyridylacetates with 3‐Indoleacetic Acids via Alkylideneindolenine Intermediates

This study reports the copper-catalyzed α-indolmethylation of 2-pyridylacetates with 3-indoleacetic acids. This reaction offers a approach to generating alkylideneindolenine electrophiles via the oxidative decarboxylation of 3-indoleacetic acids. The developed reaction system demonstrates good versatility, extending beyond the indolmethylation of 2-...

Sat Apr 13, 2024 11:32
Cobalt Catalyzed Annulation of Benzimidates or NH‐Benzaldimines with Ynamides : Synthesis of 1‐Alkoxy‐ and 1‐Alkyl‐3‐Aminoisoquinolines

Inexpensive cobalt-catalyzed, pivalic acid-assisted oxidative C-H functionalization of benzimidates or NH-benzaldimines with ynamides is presented, providing an access to 3-aminoisoquinoline derivatives. The procedure is compatible with various substrates featuring alkyl, alkoxy, acyl or halogen as substituents, heteroaryl structures, and diverse ynamides....

Sat Apr 13, 2024 11:32
Organocatalyzed, Three‐Component Construction of Cyanopyrazoles Using Diazoacetonitrile

An organocatalyzed three-component protocol using diazoacetonitrile to access a wide range of cyanopyrazole derivatives has been reported herein. This strategy, which proceeds through a piperidine-catalyzed Knoevenagel condensation/formal [3+2] cycloaddition/dehydrocyanation sequence, provides an efficient route to construct dicyanopyrazoles from aldehydes,...

Sat Apr 13, 2024 11:32
Synthesis of Alkynylsilanes: A Review of the State of the Art

This contribution offers a comprehensive overview of methods for forging sp C–Si bonds. Over time, alkynylsilanes (silylacetylenes), once considered mere byproducts of hydrosilylation processes, have become essential building blocks in organic synthesis. This literature review traces the evolution of their synthesis, from traditional methodologies relying...

Fri Apr 12, 2024 11:54
Enantioselective Si‐H Insertion of Arylvinyldiazoesters Promoted by Rhodium(I)/Diene Complexes

An enantioselective Si-H insertion between α-arylvinyldiazoesters and silanes has been developed by employing rhodium(I)/chiral diene complex as the catalyst. This protocol offers a catalytic asymmetric approach to various chiral silanes containing α-arylvinyl functionality at room temperature with good enantiocontrol (89-99% ee). Transformation of...

Fri Apr 12, 2024 11:54
Cationic [1,5]‐Aryl Migrations of Propargyl Benzyl Ethers – A Stereospecific Approach to E‐ and Z‐Tetrasubstituted Olefins

Abstract Herein we report the discovery and development of the first example of a cationic [1,5]-aryl migration reaction, through an unprecedented phenonium ions. This reaction does not require any acid, base, transition metal-based catalyst or promoter, instead promoted by the water activated NXS reagents. It provides a highly diastereoselective...

Fri Apr 12, 2024 11:54

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