Brain Pathology, EarlyView.

Decreased microvascular levels of claudin-5 in the occipital and temporal lobe of patients with cerebral amyloid angiopathy are associated with intracerebral haemorrhage.

The figure shows tissue samples taken from three previous cases, revealing the cause of hemosiderin deposition in the central nervous system because of superficial siderosis.

Our study provides an innovative approach to histologically probe challenging N-linked and O-linked post-translational modifications of sialic acid at the tissue localize modifications proximal to Alzheimer's Disease pathological aggregates. Abstract Glycosylation is the most common form of post-translational modification in the brain. Aberrant...

FAP+ pericyte-like cells drive the deposition of fibrillar extracellular matrix proteins such as collagen I and fibronectin in glioblastoma, facilitating glioma cell dissemination and activation of focal adhesion kinase. Abstract Gliomagenesis induces profound changes in the composition of the extracellular matrix (ECM) of the brain. In this...

Shotgun proteomic and confirmatory immunohistochemical characterisation of post-mortem tissue showed region-specific and HLA-DRB*15 influenced alteration in extracellular matrix proteins expression between MS and controls. In particular, we shows that non-neurological controls have a perivascular-predominant expression pattern of these proteins that...