Nature Methods - Issue - nature.com science feeds

Nature Methods is a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry relevant to the life sciences.

Latest articles

Publisher Correction: DeepCell Kiosk: scaling deep learning–enabled cellular image analysis with Kubernetes

Nature Methods, Published online: 13 January 2021; doi:10.1038/s41592-021-01059-wPublisher Correction: DeepCell Kiosk: scaling deep learning–enabled cellular image analysis with Kubernetes

Exosome detection via the ultrafast-isolation system: EXODUS

Nature Methods, Published online: 11 January 2021; doi:10.1038/s41592-020-01034-xEXODUS is a high-speed isolation method for the enrichment of exosome from biological fluids with high purity and yield.

High-accuracy long-read amplicon sequences using unique molecular identifiers with Nanopore or PacBio sequencing

Nature Methods, Published online: 11 January 2021; doi:10.1038/s41592-020-01041-yThis work presents a sequencing strategy based on unique molecular identifiers that improves long-read consensus sequence accuracy of targeted amplicons as well as shotgun whole-genome fragments.

Deciphering molecular interactions by proximity labeling

Nature Methods, Published online: 11 January 2021; doi:10.1038/s41592-020-01010-5This Review describes proximity labeling methods that make use of peroxidases (APEX) or biotin ligases (TurboID, BioID), and their applications to studying protein–protein and protein–nucleic acid interactions in living systems.

Single-objective light sheet microscopy

Nature Methods, Published online: 06 January 2021; doi:10.1038/s41592-020-01027-wSingle-objective light sheet fluorescence microscopes are driving innovation in volumetric imaging.

Scaling up multiple-genome alignments

Nature Methods, Published online: 06 January 2021; doi:10.1038/s41592-020-01045-8Scaling up multiple-genome alignments

T cell development in a dish

Nature Methods, Published online: 06 January 2021; doi:10.1038/s41592-020-01047-6T cell development in a dish

Glycoproteomics

Nature Methods, Published online: 06 January 2021; doi:10.1038/s41592-020-01028-9Glycoproteomics is coming of age, thanks to advances in instrumentation, experimental methodologies and computational search algorithms.

Assembloids

Nature Methods, Published online: 06 January 2021; doi:10.1038/s41592-020-01026-xOrganoids generated by spatially organizing multiple cell types, called assembloids, will enable deeper insights into tissue function.

More complete genomes

Nature Methods, Published online: 06 January 2021; doi:10.1038/s41592-020-01029-8Method development pushes the limit of completeness of genome sequences.

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