Nature Methods is a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry relevant to the life sciences.
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Metabuli: sensitive and specific metagenomic classification via joint analysis of amino acid and DNA

Nature Methods, Published online: 20 May 2024; doi:10.1038/s41592-024-02273-yMetabuli enhances metagenomic read classification by jointly analyzing DNA and amino acid sequences for specificity and sensitivity, respectively.

Mon May 20, 2024 13:03
DL4MicEverywhere: deep learning for microscopy made flexible, shareable and reproducible

Nature Methods, Published online: 17 May 2024; doi:10.1038/s41592-024-02295-6DL4MicEverywhere: deep learning for microscopy made flexible, shareable and reproducible

Fri May 17, 2024 13:14
Pebblescout is an easy-to-use tool for fast sequence search in petabase-scale nucleotide resources

Nature Methods, Published online: 16 May 2024; doi:10.1038/s41592-024-02281-yPebblescout navigates vast, rapidly growing nucleotide content in resources by providing indexing and search capabilities. We used Pebblescout to index a metagenomic subset of Sequence Read Archive and seven other resources into databases spanning over 3.7 petabases and searchable...

Thu May 16, 2024 23:08
Indexing and searching petabase-scale nucleotide resources

Nature Methods, Published online: 16 May 2024; doi:10.1038/s41592-024-02280-zThe Pebblescout tool achieves an efficient search for subjects in a large nucleotide database such as runs in Sequence Read Archive data.

Thu May 16, 2024 13:04
Spatial transition tensor of single cells

Nature Methods, Published online: 16 May 2024; doi:10.1038/s41592-024-02266-xSTT is a method that connects mRNA splicing and cell-state transitions across spatiotemporal scales and at single-cell resolution.

Thu May 16, 2024 13:04
Investigating immunity

Nature Methods, Published online: 14 May 2024; doi:10.1038/s41592-024-02286-7Recent methods development in immunology has galvanized our understanding of immune responses.

Tue May 14, 2024 19:45

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