Nature Methods is a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry relevant to the life sciences.
Nature Methods, Published online: 02 August 2021; doi:10.1038/s41592-021-01209-0StrucGP offers a de novo glycan mapping method to determine detailed N-glycan structures at the site-specific level.
Nature Methods, Published online: 02 August 2021; doi:10.1038/s41592-021-01207-2Two conditional transgenic mouse lines based on CRISPRa and CRISPRi enable epigenome editing in vivo.
Nature Methods, Published online: 02 August 2021; doi:10.1038/s41592-021-01203-6This Review describes spatial omics and multiplexed imaging technologies and their current and future impact in studying tumor heterogeneity and cancer biology.
Nature Methods, Published online: 29 July 2021; doi:10.1038/s41592-021-01235-yNew computational approaches capture molecular motion from cryo-EM images and provide a more complete understanding of protein dynamics.
Nature Methods, Published online: 29 July 2021; doi:10.1038/s41592-021-01220-5e2gmm uses a deep neural network with a Gaussian representation to resolve the compositional and conformational variability within biomolecules using cryo-EM data.
Nature Methods, Published online: 27 July 2021; doi:10.1038/s41592-021-01205-4DOME is a set of community-wide recommendations for reporting supervised machine learning–based analyses applied to biological studies. Broad adoption of these recommendations will help improve machine learning assessment and reproducibility.
Nature Methods, Published online: 27 July 2021; doi:10.1038/s41592-021-01232-1I do not think you can start with anything precise. You have to achieve such precision as you can, as you go along. —Bertrand Russell
Nature Methods, Published online: 26 July 2021; doi:10.1038/s41592-021-01219-yA four-dimensional single-cell atlas of transcription factor expression in Caenorhabditis elegans allows the identification of novel regulators of embryo development and the generation of molecular models of cell fate specification.
Nature Methods, Published online: 26 July 2021; doi:10.1038/s41592-021-01216-1A protein expression atlas of transcription factors charted onto cell lineage maps of Caenorhabditis elegans development that uncovers mechanisms of spatiotemporal cell fate patterning and regulators of embryogenesis.
Nature Methods, Published online: 26 July 2021; doi:10.1038/s41592-021-01208-1RAPID (rapid autofocusing via pupil-split image phase detection) is a sample-agnostic real-time autofocus method for widefield microscopy. RAPID removes most image degradation in large, cleared samples for enhanced quantitative analyses.
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