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Nature Methods is a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry relevant to the life sciences.

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Detecting chromatin interactions between and along sister chromatids with SisterC

Nature Methods, Published online: 23 September 2020; doi:10.1038/s41592-020-0930-9It remains impossible using conventional Hi-C to differentiate interactions between and along sister chromatids. SisterC relies on selective destruction of nascent DNA and in combination with Hi-C offers a means to study intra- and inter-sister interactions independently.

Plasmonic scattering imaging of single proteins and binding kinetics

Nature Methods, Published online: 21 September 2020; doi:10.1038/s41592-020-0947-0Plasmonic scattering microscopy (PSM) enables the imaging of single proteins on SPR instruments. The method enables measurement of protein size and binding kinetics and is fully compatible with simultaneous traditional SPR measurements.

Genuage: visualize and analyze multidimensional single-molecule point cloud data in virtual reality

Nature Methods, Published online: 21 September 2020; doi:10.1038/s41592-020-0946-1An open-source software platform, Genuage, enables the easy perception of, interaction with and analysis of multidimensional point clouds in virtual reality.

In vivo detection of antigen-specific CD8<sup>+</sup> T cells by immuno-positron emission tomography

Nature Methods, Published online: 14 September 2020; doi:10.1038/s41592-020-0934-5Antigen-specific CD8+ T cells can be imaged by immunoPET with the help of synTacs, MHC-based tools that bind to relevant T-cell receptors.

Live-cell super-resolved PAINT imaging of piconewton cellular traction forces

Nature Methods, Published online: 14 September 2020; doi:10.1038/s41592-020-0929-2Tension-PAINT integrates molecular tension probes with DNA-PAINT to enable ~25-nm-resolution mapping of piconewton mechanical events. Tension-PAINT can be used to study dynamic forces, and an irreversible variant integrates force history over time.

MassIVE.quant: a community resource of quantitative mass spectrometry–based proteomics datasets

Nature Methods, Published online: 14 September 2020; doi:10.1038/s41592-020-0955-0MassIVE.quant is a data repository and data resource for reproducible quantitative mass spectrometry–based proteomics.

Manu Prakash

Nature Methods, Published online: 10 September 2020; doi:10.1038/s41592-020-0968-8Frugally built technology to study the ocean’s microbes, and engineering for societal good.

Reality check for organoids in neuroscience

Nature Methods, Published online: 09 September 2020; doi:10.1038/s41592-020-0964-zTo better study human neurodevelopment, researchers advance organoids as brain models.

Author Correction: Nested designs

Nature Methods, Published online: 09 September 2020; doi:10.1038/s41592-020-0969-7Author Correction: Nested designs

Addendum: Parameter-free image resolution estimation based on decorrelation analysis

Nature Methods, Published online: 08 September 2020; doi:10.1038/s41592-020-0963-0Addendum: Parameter-free image resolution estimation based on decorrelation analysis

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