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Nature Methods is a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry relevant to the life sciences.

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StrucGP: de novo structural sequencing of site-specific N-glycan on glycoproteins using a modularization strategy

Nature Methods, Published online: 02 August 2021; doi:10.1038/s41592-021-01209-0StrucGP offers a de novo glycan mapping method to determine detailed N-glycan structures at the site-specific level.

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

Nature Methods, Published online: 02 August 2021; doi:10.1038/s41592-021-01207-2Two conditional transgenic mouse lines based on CRISPRa and CRISPRi enable epigenome editing in vivo.

Spatial omics and multiplexed imaging to explore cancer biology

Nature Methods, Published online: 02 August 2021; doi:10.1038/s41592-021-01203-6This Review describes spatial omics and multiplexed imaging technologies and their current and future impact in studying tumor heterogeneity and cancer biology.

Neural networks learn the motions of molecular machines

Nature Methods, Published online: 29 July 2021; doi:10.1038/s41592-021-01235-yNew computational approaches capture molecular motion from cryo-EM images and provide a more complete understanding of protein dynamics.

Deep learning-based mixed-dimensional Gaussian mixture model for characterizing variability in cryo-EM

Nature Methods, Published online: 29 July 2021; doi:10.1038/s41592-021-01220-5e2gmm uses a deep neural network with a Gaussian representation to resolve the compositional and conformational variability within biomolecules using cryo-EM data.

DOME: recommendations for supervised machine learning validation in biology

Nature Methods, Published online: 27 July 2021; doi:10.1038/s41592-021-01205-4DOME is a set of community-wide recommendations for reporting supervised machine learning–based analyses applied to biological studies. Broad adoption of these recommendations will help improve machine learning assessment and reproducibility.

Graphical assessment of tests and classifiers

Nature Methods, Published online: 27 July 2021; doi:10.1038/s41592-021-01232-1I do not think you can start with anything precise. You have to achieve such precision as you can, as you go along. —Bertrand Russell

The long and winding road of development: a coordinated song of transcription factors

Nature Methods, Published online: 26 July 2021; doi:10.1038/s41592-021-01219-yA four-dimensional single-cell atlas of transcription factor expression in Caenorhabditis elegans allows the identification of novel regulators of embryo development and the generation of molecular models of cell fate specification.

A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis

Nature Methods, Published online: 26 July 2021; doi:10.1038/s41592-021-01216-1A protein expression atlas of transcription factors charted onto cell lineage maps of Caenorhabditis elegans development that uncovers mechanisms of spatiotemporal cell fate patterning and regulators of embryogenesis.

Universal autofocus for quantitative volumetric microscopy of whole mouse brains

Nature Methods, Published online: 26 July 2021; doi:10.1038/s41592-021-01208-1RAPID (rapid autofocusing via pupil-split image phase detection) is a sample-agnostic real-time autofocus method for widefield microscopy. RAPID removes most image degradation in large, cleared samples for enhanced quantitative analyses.

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