Time for NanoNeuro

Nature Methods, Published online: 18 October 2021; doi:10.1038/s41592-021-01270-9This Perspective discusses how neuroscience can benefit from harnessing nanoscience-based tools for manipulating and recording neuronal activity.

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MethodsJ2: a software tool to capture metadata and generate comprehensive microscopy methods text

Nature Methods, Published online: 15 October 2021; doi:10.1038/s41592-021-01290-5MethodsJ2: a software tool to capture metadata and generate comprehensive microscopy methods text

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The class imbalance problem

Nature Methods, Published online: 15 October 2021; doi:10.1038/s41592-021-01302-4The exception proves the rule.

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Removing independent noise in systems neuroscience data using DeepInterpolation

Nature Methods, Published online: 14 October 2021; doi:10.1038/s41592-021-01285-2DeepInterpolation is a self-supervised deep learning-based denoising approach for calcium imaging, electrophysiology and fMRI data. The approach increases the signal-to-noise ratio and allows extraction of more information from the processed data than from the raw data.

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MDEmic: a metadata annotation tool to facilitate management of FAIR image data in the bioimaging community

Nature Methods, Published online: 11 October 2021; doi:10.1038/s41592-021-01288-zMDEmic: a metadata annotation tool to facilitate management of FAIR image data in the bioimaging community

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Mapping genome structures in single cells

Nature Methods, Published online: 04 October 2021; doi:10.1038/s41592-021-01294-1Researchers develop single-cell SPRITE to detect higher-order 3D genome structures in single cells.

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Keeping checks on machine learning

Nature Methods, Published online: 04 October 2021; doi:10.1038/s41592-021-01300-6Community-driven initiatives are proposing standards to improve the reporting and reproducibility of machine learning in biology. We support these developments, some of which are described in this month’s special issue.

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Nanopore-detectable reporter proteins

Nature Methods, Published online: 04 October 2021; doi:10.1038/s41592-021-01297-yNanoporeTERs, engineered reporter proteins, can be detected on MinION nanopore sensor arrays.

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Reprogrammed anti-tumor NK cells

Nature Methods, Published online: 04 October 2021; doi:10.1038/s41592-021-01296-zReprogrammed natural killer cells show enhanced functional properties and anti-tumor efficacy.

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Spike inference with CASCADE

Nature Methods, Published online: 04 October 2021; doi:10.1038/s41592-021-01295-0A deep-learning-based tool and a large ground truth dataset enable spike inference from calcium imaging data acquired in a variety of experimental conditions.

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