Chemosphere. 2021 Jun 8:131030. doi: 10.1016/j.chemosphere.2021.131030. Online ahead of print.ABSTRACTIn current times of global change, several sources of stress such as contaminants and high temperatures may act synergistically. The extent to which organisms persist in stressful conditions will depend on the fitness consequences of multiple simultaneously...

Biochem Biophys Res Commun. 2021 Jun 15;566:197-203. doi: 10.1016/j.bbrc.2021.05.071. Online ahead of print.ABSTRACTMaytansinoids, the chemical derivatives of Maytansine, are commonly used as potent cytotoxic payloads in antibody-drug conjugates (ADC). Structure-activity-relationship studies had identified the C3 ester side chain as a critical element...

Angew Chem Int Ed Engl. 2021 Jun 18. doi: 10.1002/anie.202105790. Online ahead of print.ABSTRACTAutocatalytic reaction networks are instrumental for validating scenarios for the emergence of life on Earth and for synthesizing life de novo . It is well understood how the selection of specific molecules occurs in reaction networks driven by template-assisted...

ACS Med Chem Lett. 2021 May 18;12(6):983-990. doi: 10.1021/acsmedchemlett.1c00126. eCollection 2021 Jun 10.ABSTRACTConformation-dependent 3D descriptors have been shown to provide better predictions of the physicochemical properties of macrocycles than 2D descriptors. However, the computational identification of relevant conformations for macrocycles...

Chemistry. 2021 Jun 17. doi: 10.1002/chem.202101515. Online ahead of print.ABSTRACTWe investigated the photoionization and fragmentation of isolated metal protoporphyrin IX cations (MPPIX with M = Fe, Co, Zn) by means of VUV action spectroscopy in the energy range of 8.5-35 eV. Experiments were carried out in the gas phase by interfacing an electrospray...

Inorg Chem. 2021 Jun 16. doi: 10.1021/acs.inorgchem.1c01039. Online ahead of print.ABSTRACTThe reaction of a carbatripyrrin with a tellurophene dicarbinol in the presence of BF3·Et2O, followed by oxidation with DDQ, afforded the first example of a telluracarbaporphyrin. Although this system exhibits strongly aromatic characteristics, it is prone to...