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The drumbeat of complaints over the poor treatment of graduate students and postdocs in academic science continues. As explained on this page, there is a seemingly endless “slow-motion crisis” of strikes, failures at collective bargaining, and damaging news stories about the mistreatment of and poor working conditions for graduate students. Meanwhile,...
Numerous nonantibiotic drugs have potent antibacterial activity and can adversely impact the human microbiome. The mechanistic underpinning of this toxicity remains largely unknown. We investigated the antibacterial activity of 200 drugs using genetic ...
Newly copied sister chromatids are tethered together by the cohesin complex, but how sister chromatid cohesion is coordinated with DNA replication is poorly understood. Prevailing models suggest cohesin complexes, bound to DNA before replication, remain ...
Deep learning methods have revolutionized protein structure prediction and design but are currently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA) which combines a residue-based representation of amino acids and DNA bases with ...
A unified mechanism without backpropagation characterizes feature learning in neural network architectures.
A combination therapy–induced vaccinal effect can induce long-term remission from SHIV infection after ART discontinuation.
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