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Mitochondria metabolism sets the species-specific tempo of neuronal development | Science

Neuronal development in the human cerebral cortex is considerably prolonged compared to that of other mammals. We explored whether mitochondria influence the species-specific timing of cortical neuron maturation. By comparing human and mouse cortical ...

Exon architecture controls mRNA m6A suppression and gene expression | Science

N6–methyladenosine (m6A) is the most abundant mRNA modification and plays crucial roles in diverse physiological processes. Utilizing a Massively Parallel Assay for m6A (MPm6A), we discover that m6A specificity is globally regulated by “suppressors” that ...

Revolt against educational rankings | Science

The ranking of universities and colleges at the national and global level is a well-known dubious practice. Flawed methodologies generate distorted and inaccurate profiles of these institutions. Yet, rankings have remained a popular and trusted measure of “the best” by the public. U.S. News & World Report has long held a stranglehold on US higher...

Asymmetric counteranion-directed photoredox catalysis | Science

Photoredox catalysis enables unique and broadly applicable chemical reactions but controlling their selectivity has proven to be difficult. The pursuit of enantioselectivity is a particularly daunting challenge, arguably due to the high energy of the ...

The Pāhala swarm of earthquakes in Hawaiʻi | Science

A magma network may feed into different volcanoes, including Mauna Loa and Kīlauea

The magmatic web beneath Hawai‘i | Science

The deep magmatic architecture of the Hawaiian volcanic system is central to understanding the transport of magma from the upper mantle to the individual volcanoes. We leverage advances in earthquake monitoring with deep learning algorithms to image the ...

Retraction | Science

In the Research Article “Gradual emergence followed by exponential spread of the SARS-CoV-2 Omicron variant in Africa” (1), we reported data from retrospective characterization of viral genomes of putative ancestors of the SARS-CoV-2 Omicron variant from western Africa months before the first detection of Omicron. After several social media posts suggested...

Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children | Science

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic dsRNA-sensing OAS1 ...

Appoint a new NIH director, now | Science

Why has President Biden’s administration been staggering when it comes to key scientific appointments? Most noticeably, there has been a failure to confirm a new director of the National Institutes of Health (NIH) since Francis Collins stepped down a year ago. It took nearly a year to nominate the Commissioner of the Food and Drug Administration (FDA),...

Structure of monkeypox virus DNA polymerase holoenzyme | Science

A high-resolution structure of the replicating state of orthopoxvirus DNA polymerase is determined.

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