Angewandte Chemie International Edition

Wiley Online Library : Angewandte Chemie International Edition

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A minimal sequence for left‐handed G‐quadruplex formation

Recently, we observed the first example of a left‐handed G‐quadruplex structure formed by natural DNA, named Z‐G4. We analysed the Z‐G4 structure and inspected its primary 28‐nt sequence in order to identify motifs that convey the unique left‐handed twist. Using CD, NMR spectroscopy and X‐ray crystallography, we revealed a minimal sequence motif of...

Direct evidence for ferrous ions oxidation and incorporation in absence of oxidants by Dps from Marinobacter hydrocarbonoclasticus.

Dps (DNA‐binding protein from starved cells) proteins are hollow sphere shaped, dodecameric enzymes found in bacteria and archaeal species. They are able to oxidize ferrous iron in a controlled manner using hydrogen peroxide or molecular oxygen as co‐substrate and most of them confer physical protection through DNA binding. Oxidized iron is stored,...

Taming Radical Intermediates for the Construction of Enantioenriched Trifluoromethylated Quaternary Carbon Centers

We demonstrate the construction of trifluoromethylated quaternary carbon centers via an asymmetric radical transformation. Enantioenriched trifluoromethylated oxindoles were accessed through the use of a hypervalent iodine‐based trifluoromethyl transfer reagent in combination with a magnesium Lewis acid catalyst and PyBOX‐type ligands to achieve up...

Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3‐Arylpyrroles

We report herein the first examples of catalytic enantioselective synthesis of axially chiral 3‐arylpyrroles. Reaction of α‐isocyanoacetates with β‐aryl‐α,β‐alkynic ketones in the presence of silver oxide and a phosphine ligand derived from Cinchona alkaloid occurred chemoselectively to afford enantioenriched 3‐arylpyrroles in high yields with excellent...

New Roles for Photoexcited Eosin Y in Photochemical Reactions

New sides of eosin Y: Neutral eosin Y‐derived photoexcited states have been found to serve as photoacids and direct hydrogen atom transfer (HAT) catalysts in the activation of glycals and C−H bonds, respectively. These studies pave the way for further use of eosin Y in photochemical synthesis. Abstract Neutral eosin Y‐derived photoexcited states...

Supramolecular Capsules: Strong versus Weak Chalcogen Bonding

Strengths and weaknesses: Dimeric chalcogen‐bonding capsules display a distinct behavior depending on the association strength, as shown by X‐ray structures and confirmed by NMR spectroscopy solution studies. While capsules based on weak S⋅⋅⋅N interactions rely on solvation and the associated hemisphere preorganization, capsular assemblies formed by...

Autonomic Behavior in Lipase‐active Oil Droplets

Developing self‐fueled micro‐reactor droplets with programmable autonomic behaviors provides a step towards smart liquid dispersions comprising motile microscale objects. Here we prepare aqueous suspensions of lipase‐coated oil globules comprising a mixture of a triglyceride substrate (tributyrin, 1,2,3‐tributylglycerol) and a low‐density oil (polydimethylsiloxane,...

Blue Light Induced Carbene Transfer Reactions of Diazoalkanes

Carbenes are very important reactive intermediates to access a variety of complex molecules and possess widespread application in organic synthesis or drug discovery. Typically, their chemistry is accessed by the use of transition metal catalysts. Herein, we describe the application of low energy blue light for the photochemical generation of carbenes...

Synthetic Polyester from Plant Oil Feedstock by Functionalizing Polymerization

Catalytic functionalization/polymerization of castor oil‐derived undecenol yields an aliphatic polyester in a single step under mild conditions. The key to selective formation of linear high melting polyester is highly active carbonylation catalysts that at the same time do not undergo strong isomerization.

A hydrostable cathode material based on the layered P2@P3 composite with revealed redox behavior of Cu for high‐rate and long cycling sodium‐ion batteries

Viewing from the perspective of sustainable development, the low‐cost layered oxides without Ni or Co are considered to be the most promising type of cathode materials for future sodium‐ion batteries. The atmospheric and electrochemical corrosion occurring at the interfaces of layered cathodes, however, results in serious degradation of both the capacity...

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