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Assessing Direct and Spillover Effects of Intervention Packages in Network-randomized Studies

Background: Intervention packages may result in a greater public health impact than single interventions. Understanding the separate impact of each component on the overall package effectiveness can improve intervention delivery. Methods: We adapted an approach to evaluate the effects of a time-varying intervention package in a network-randomized...

Wed May 8, 2024 03:18
Comparing PCSK9 Monoclonal Antibody Treatment Strategies Following Myocardial Infarction Using Negative Control Outcomes: A Target Trial Emulation Study

Background: Initiation of proprotein convertase subtilisin/kexin type 9 monoclonal antibody (PCSK9 mAb) for lipid-lowering following myocardial infarction (MI) is likely affected by patients’ prognostic factors, potentially leading to bias when comparing real-world treatment effects. Methods: Using target-trial emulation,...

Wed Apr 24, 2024 01:46
Improving Inverse Probability Weighting by Post-calibrating Its Propensity Scores

Theoretical guarantees for causal inference using propensity scores are partially based on the scores behaving like conditional probabilities. However, scores between zero and one do not necessarily behave like probabilities, especially when output by flexible statistical estimators. We perform a simulation study to assess the error in estimating the...

Tue Apr 16, 2024 07:15

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