by Bianca A. Schuster, Sophie Sowden, Alicia J. Rybicki, Dagmar S. Fraser, Clare Press, Lydia Hickman, Peter Holland, Jennifer L. Cook Difficulties in reasoning about others’ mental states (i.e., mentalising/Theory of Mind) are highly prevalent among disorders featuring dopamine dysfunctions (e.g., Parkinson’s disease) and significantly affect...

by Benjamin V. Ineichen, Eva Furrer, Servan L. Grüninger, Wolfgang E. Zürrer, Malcolm R. Macleod There is an ongoing debate about the value of animal experiments to inform medical practice, yet there are limited data on how well therapies developed in animal studies translate to humans. We aimed to assess 2 measures of translation across various...

by Annafrancesca Rigato, Huicheng Meng, Claire Chardes, Adam Runions, Faris Abouakil, Richard S. Smith, Loïc LeGoff The polygonal shape of cells in proliferating epithelia is a result of the tensile forces of the cytoskeletal cortex and packing geometry set by the cell cycle. In the larval Drosophila epidermis, two cell populations, histoblasts...

by Jingjing Wei, Jingtong Liu, Ziwen Wang, Yuan Yang, Yuwen Tian, Shengzhou Wang, Bao-Qing Gao, Song Gao, Li Yang, Junnan Tang, Yongming Wang CRISPR-Cas12a, often regarded as a precise genome editor, still requires improvements in specificity. In this study, we used a GFP-activation assay to screen 14 new Cas12a nucleases for mammalian genome editing,...

by Yassine Cherrak, Miguel Angel Salazar, Koray Yilmaz, Markus Kreuzer, Wolf-Dietrich Hardt The gastrointestinal tract is densely colonized by a polymicrobial community known as the microbiota which serves as primary line of defence against pathogen invasion. The microbiota can limit gut-luminal pathogen growth at different stages of infection....

by Leah R. Gerber, Gwenllian D. Iacona The planetary outlook for biodiversity is dire. A new collection of articles discusses the disconnect between the data we have and the data we need for more effective action on conservation, as well as how social justice and end-user viewpoints must be centered to ensure a more sustainable future for our planet....