Advanced Healthcare Materials
In this article, Yu, da Silva and Grigoriadis establish an injectable polyethylene glycol hydrogel system crosslinked by the interaction between calcium phosphates and alendronate. These degradable hydrogels, bearing tunable stress relaxation and stiffness, keep a stable, self-healing network structure and are suitable for the culture of various cancer...
A novel approach is reported by integrating bioprinting and microfluidic technologies to create a multi-composition tumor array that mimics the complex transport in the tumor microenvironment (TME). This approach enables the self-organized formation of a vascular barrier around tumor spheroids and comprehensively evaluates drug efficacy across different...
In this study, prefabricated TiN nanodots and Fe(CO)5 nanoparticles are combined into sodium alginate hydrogels to create a biomedical material for the topical treatment of breast cancer and subcutaneous abscesses, and a pseudocatalytic hydrogel with intrinsic photothermal and antibacterial activities is synthesized. The addition of the hydrogel causes...
Abstract Ferroptosis induction is particularly promising for cancer therapy when the apoptosis pathway is compromised. Current strategies in nanomedicine for inducing ferroptosis primarily focus on promoting the accumulation of reactive oxygen species (ROS). However, the presence of intracellular antioxidants, such as nuclear factor erythroid 2-related...
Abstract Despite laparoscopic-guided minimally invasive hepatectomy emerging as the primary approach for resecting hepatocellular carcinoma (HCC), there's still a significant gap in suitable biomaterials that seamlessly integrate with these techniques to achieve effective hemostasis and suppress residual tumors at the surgical margin. Electrospun films...
This study introduces a biomimetic approach using 1-O-acylceramide to fabricate stable multilamellar lipid vesicles for enhanced antigen delivery in vaccines. These vesicles withstand environmental stresses and induce stronger immune responses in vitro and in vivo compared to traditional unilamellar vesicles, showing promise as an effective nanovaccine...