Nature Genetics, Published online: 03 May 2024; doi:10.1038/s41588-024-01721-xDefining minimal standards for data collection is key to creating interoperative, searchable genomic and clinical databases. We highlight here the 1+Million Genomes Minimal Dataset for Cancer, encompassing 140 items in 8 domains to foster the collection of cancer data, inform...

Nature Genetics, Published online: 01 May 2024; doi:10.1038/s41588-024-01737-3Genome assemblies of four filamentous Zygnematophyceae and co-expression network analyses shed light on the evolutionary roots of the mechanism for balancing environmental responses and multicellular growth.

Nature Genetics, Published online: 30 April 2024; doi:10.1038/s41588-024-01704-ySBayesRC integrates genome-wide association summary statistics with functional annotations to improve polygenic prediction of complex traits. Functional partitioning highlights a major contribution of evolutionarily constrained regions to prediction accuracy.

Nature Genetics, Published online: 30 April 2024; doi:10.1038/s41588-024-01714-wGenome-wide association analysis in over one million individuals of European ancestry identifies 2,103 independent genetic signals (including 113 new loci) associated with blood pressure traits.

Nature Genetics, Published online: 29 April 2024; doi:10.1038/s41588-024-01734-6We construct a chromosome-level genome assembly of the acorn barnacle Amphibalanus amphitrite. Using this genome together with multi-omics datasets and functional evidence, we reveal the evolution and function of two lineage-specific genes, bcs-6 and bsf, that help A. amphitrite...

Nature Genetics, Published online: 29 April 2024; doi:10.1038/s41588-024-01719-5Long-read sequencing identifies a GGC-repeat expansion in the coding region of ZFHX3 as the cause of spinocerebellar ataxia type 4. The expansion encodes polyglycine and results in intranuclear aggregates and abnormal autophagy.