Evaluation of the human antibody response to Zika virus has identified common germline-derived mAbs capable of cross flavivirus neutralization. Zhao et al. provide a detailed mechanistic understanding of how flavivirus infections are prevented in a strain-specific manner by a representative mAb.

This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis. CFIm25 downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm25 restoration attenuates skin fibrosis.

Single-cell transcriptome analysis of epithelial cells from human ileum, colon, and rectum reveals different nutrient-absorption preferences in the small and large intestine, providing a rich resource for further characterization of human intestine cell constitution and functions.

A super enhancer termed DR/DQ-SE within the MHC-II locus was examined by CRISPR mutagenesis. DR/DQ-SE was found to regulate HLA-DRB1, -DQA1, and -DQB1 gene expression by controlling chromatin interactions/looping between MHC-II gene promoters and CTCF binding elements.

Arroyo and Pepper demonstrate that interactions with B cells, not dendritic cells, are required for the priming of the CD4+ T cell response during Plasmodium infection. This results in a Tfh-biased response as reported by others in both mice and humans.

Vol. 216, No. 11, November 4, 2019. 10.1084/jem.20180371.The authors regret that in their original paper, the TNBS+anti-Ly6G+T2AA image in Fig. 8 D was incorrect as a result of an error during figure preparation. In addition, y axes and...