Abstract Nanoparticle physicochemical properties have received great attention in optimizing the performance of nanoparticles for biomedical applications. For example, surface functionalization with small molecules or linear hydrophilic polymers is commonly used to tune the interaction of nanoparticles with proteins and cells. However, it is challenging...

A photoelectric flow sensor based on a flexible planar curved beam structure with characteristics such as high sensitivity, a wide detection range, and commendable repeatability in detecting both gases and liquids is proposed. The proposed flow rate sensors cost less than five dollars per unit, much lower than current flow sensors used in clinical...

Abstract More than three years into the global pandemic, SARS-CoV-2 remains a significant threat to public health. Immunities acquired from infection or current vaccines fail to provide long term protection against subsequent infections, mainly due to their fast-waning nature and the emergence of variants of concerns (VOCs) such as Omicron. To overcome...

TAFsomes and CCMsomes, specialized membrane fusion liposomes, are developed. These liposomes, loaded with pirfenidone and doxorubicin, specifically target tumor-associated fibroblasts and tumor cells, respectively. This targeted approach aims to reshape the tumor microenvironment and boost chemotherapy efficacy. By adjusting drug delivery ratios and...

In vitro results show that the GHM@RD scaffolds achieve good angiogenic-osteogenic coupling by activating the PI3K/AKT/HSP90 pathway in BMSCs and the PI3K/AKT/HIF-1α pathway in HUVECs under mild thermotherapy. In vivo experiments reveal that RD and mild hyperthermia synergistically induce early vascularization and bone regeneration of critical bone...

Tetrahedral DNA nanostructures incorporating hypoxia response elements, termed as “HIF-1α DNA yokes,” are synthesized as nanodrugs for cancer treatment. These HIF-1α DNA yokes demonstrate efficient internalization into cancer cells and subsequent binding to HIF-1α, triggering its degradation and concomitant inhibition of its transcriptional activity....