High levels of cytosolic citrate originated from endogenous accumulation and exogenous intake can strongly inhibit glycolytic enzymes during M1 macrophage polarization than M2 macrophage polarization and turn the metabolism of macrophages to oxidative phosphorylation of M2 macrophage, largely reversing osteoporotic bone homeostasis. Abstract...

Here a 3D-bioprinted heart valve is introduced as a solution to aortic valve disease, especially in pediatric patients. It features a trilayer leaflet structure using a gelatin methacrylate and polyethylene glycol diacrylate (GelMA/PEGDA) hydrogel scaffold with valvular interstitial-like (VIC-like) cells and a polycaprolactone (PCL) layer. The scaffold...

The extracellular matrix (ECM) regulates cellular activities crucial for tissue development, including growth, differentiation, and repair. Proper orchestration of instructive cues by the ECM is essential for correct tissue development; failure leads to dysfunction. This review illustrates the ECM's regulatory potency in tissue morphogenesis in vitro...

Abstract Current research in cancer therapy focuses on personalized therapies, through nanotechnology-based targeted drug delivery systems. Particularly, controlled drug release with core-shell nanoparticles can be designed to safely transport various active agents, optimizing delivery to specific organs and tumors, minimizing side effects. The use...

Abstract Here, a novel porous microneedle (PMN) device with bilaterally aligned electroosmotic flow (EOF) enabling controllable dual-mode delivery of molecules is developed. The PMNs placed at anode and cathode compartments are modified with anionic PAMPS (poly-2-acrylamido-2-methyl-1-propanesulfonic acid) and cationic PAPTAC (poly-(3-acrylamidopropyl)...

This study successfully fabricates a multifunctional integrated composite scaffold using 3D printing technology, which encompasses nanosilver, graphene oxide, and macrophage membrane vesicles. This composite scaffold demonstrates excellent antibacterial, immunomodulatory, and osteogenic properties, and exhibits favorable biocompatibility in vivo....