The Deterioration in CD8+ T Cell Function and Interactive Dynamics between CD8+ T Cells and Tumor Cells Play a Vital Role in the Development of occult lymph node metastasis (OLNM) in non-small cell lung cancer (NSCLC). Strategies aimed at improving hypoxia or targeting cancer microvessels (CMVs) could potentially enhance the efficacy of immunotherapy...

SNHG15 can be transcriptionally activated by E2F1 and MYC. Subsequently, SNHG15 forms a molecular decoy for miR-24-3p, a miRNA targeting E2F1 and MYC for degradation, thereby contributing to increased expression of E2F1 and MYC. SNHG15 also enhances the stability of SLC7A11 in the cytoplasm by binding HNRNPA1, and inhibits ferroptosis through an HNRNPA1-dependent...

In this study, we summarized the trend of treatment and survival of colorectal cancer patients from 1995 to 2015 in six Japanese prefectures. The proportion of laparoscopic surgery has risen since 2005, and the combination of laparoscopic surgery and chemotherapy has also increased. Five-year net survival of laparoscopic surgery patients stayed high,...

Although occurring at low frequencies, HER2 activating mutations have emerged as oncogenic drivers and therapeutic targets in breast cancer. Outlining a role in therapeutic resistance, newly acquired HER2 deregulations are frequently detected in patients who experience disease progression following both endocrine and HER2-targeted therapies. Novel...

In this study, we undertook a comprehensive investigation into the roles and molecular mechanisms of circular RNA molecule circESYT2 in hepatocellular carcinoma (HCC). The findings revealed a significant association between circESYT2 overexpression and worse prognosis in HCC patients. Mechanistically, we identified for the first time that circESYT2...

We found that CD271 mRNA, but not CD271 protein, plays a role in the sphere proliferation of cancer cells. The CD271 mRNA bound to the hnRNPA2B1 protein, an RNA-binding protein that promotes tumor malignancy. Abstract RNAs, such as noncoding RNA, microRNA, and recently mRNA, have been recognized as signal transduction molecules. CD271, also known...