Abstract figure legend Air pollution affects most of the planet's population. Unsurprisingly, pollution-related chronic respiratory conditions and cardiovascular disease are becoming more prevalent, but emerging data suggest that airborne particulate matter exposure also impacts neurodevelopment and may play a role in neurodegeneration. In this study,...

Abstract figure legend A coarse approximation of the organization of white matter tracts that transmit descending commands from cortical motor areas to spinal motor neuron pools. Fibres that roughly segregate into each tract at the level of the brainstem overlap in cortical origin and intermingle throughout their cranial course. Corticospinal fibres...

Abstract figure legend Considerations for altitude travel in pulmonary vascular disease patients, focusing on sensible pre-travel evaluation, possible altitude-related adverse events and their management. Abstract Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension are the main precapillary forms of pulmonary...

Abstract figure legend Natural selection might act on homeostatic regulatory mechanisms and on other control mechanisms including homeorhesis where different stable stationary states are reached. Regeneration is under homeostatic control and damage to tissues initiates a response to restore the equilibrium, whereas repair is a homeorhetic change leading...

Abstract figure legend A summary diagram illustrating the progression of autonomic dysfunction following cardiac injury or disease, and some of the tools used for investigating and/or manipulating neural and cardiac function. Afferent neurotransmission is increased and may contribute to the pathological remodelling of efferent autonomic activity,...

Abstract figure legend An acute bout of exercise can increase circulating cytokine concentrations and immune cell counts. Our findings show that these systemic increases in anti-inflammatory cytokines and immune cell counts are paralleled by a hyporesponsiveness to anti-inflammatory cytokine action – as reflected by the blunted activation of intracellular...