Mol Med. 2024 May 21;30(1):65. doi: 10.1186/s10020-024-00818-7.ABSTRACTOBJECTIVE: Catalpol (CAT) has various pharmacological activities and plays a protective role in cerebral ischemia. It has been reported that CAT played a protective role in cerebral ischemia by upregulaing NRF1 expression. Bioinformatics analysis reveals that NRF1 can be used as...

Parasitol Res. 2024 May 22;123(5):217. doi: 10.1007/s00436-024-08231-z.ABSTRACTToxoplasmosis poses a global health threat, ranging from asymptomatic cases to severe, potentially fatal manifestations, especially in immunocompromised individuals and congenital transmission. Prior research suggests that oregano essential oil (OEO) exhibits diverse biological...

Amino Acids. 2024 May 21;56(1):36. doi: 10.1007/s00726-024-03395-5.ABSTRACTIn the initial stages of Alopecia Areata (AA), the predominance of hair breakage or exclamation mark hairs serves as vital indicators of disease activity. These signs are non-invasive and are commonly employed in dermatoscopic examinations. Despite their clinical salience, the...

Chem Biol Drug Des. 2024 May;103(5):e14535. doi: 10.1111/cbdd.14535.ABSTRACTDespite efforts, available alternatives for the treatment of leishmaniasis are still scarce. In this work we tested a class of 15 quinolinylhydrazone analogues and presented data that support the use of the most active compound in cutaneous leishmaniasis caused by Leishmania...

J Zhejiang Univ Sci B. 2024 May 14:1-14. doi: 10.1631/jzus.B2300917. Online ahead of print.ABSTRACTEnd-stage liver diseases, such as cirrhosis and liver cancer caused by hepatitis B, are often combined with hepatic encephalopathy (HE); ammonia poisoning is posited as one of its main pathogenesis mechanisms. Ammonia is closely related to autophagy, but...

Redox Biol. 2024 May 16;73:103196. doi: 10.1016/j.redox.2024.103196. Online ahead of print.ABSTRACTHippocampal neural stem/progenitor cells (NSPCs) are highly vulnerable to different stress stimuli, resulting in adult neurogenesis decline and eventual cognitive defects. Our previous study demonstrated that NOD-like receptor family pyrin domain-containing...