Cell Mol Life Sci. 2024 May 22;81(1):227. doi: 10.1007/s00018-024-05274-4.ABSTRACTProteins delivered by endocytosis or autophagy to lysosomes are degraded by exo- and endoproteases. In humans 15 lysosomal cathepsins (CTS) act as important physiological regulators. The cysteine proteases CTSB and CTSL and the aspartic protease CTSD are the most abundant...

Mol Neurobiol. 2024 May 22. doi: 10.1007/s12035-024-04230-4. Online ahead of print.ABSTRACTAutophagy is an intracellular recycling process that maintains cellular homeostasis by degrading excess or defective macromolecules and organelles. Chaperone-mediated autophagy (CMA) is a highly selective form of autophagy in which a substrate containing a KFERQ-like...

FASEB J. 2024 May 31;38(10):e23677. doi: 10.1096/fj.202400222RR.ABSTRACTAlthough the use of Doxorubicin (Dox) is extensive in the treatment of malignant tumor, the toxic effects of Dox on the heart can cause myocardial injury. Therefore, it is necessary to find an alternative drug to alleviate the Dox-induced cardiotoxicity. Dihydroartemisinin (DHA)...

J Cell Biol. 2024 Aug 5;223(8):e202309145. doi: 10.1083/jcb.202309145. Epub 2024 May 22.ABSTRACTAutophagy is an important metabolic pathway that can non-selectively recycle cellular material or lead to targeted degradation of protein aggregates or damaged organelles. Autophagosome formation starts with autophagy factors accumulating on lipid vesicles...

Heliyon. 2024 May 9;10(9):e30766. doi: 10.1016/j.heliyon.2024.e30766. eCollection 2024 May 15.ABSTRACTProstate cancer (PCa) is the most common malignancy of the male urinary system. Mitophagy, as a type of autophagy, can remove damaged mitochondria in cells. Mitophagy-related genes (MRGs) have been shown to play critical roles in the development of...

Front Microbiol. 2024 May 7;15:1384459. doi: 10.3389/fmicb.2024.1384459. eCollection 2024.ABSTRACTPine wilt disease caused by Bursaphelenchus xylophilus poses a serious threat to the economic and ecological value of forestry. Nematode trapping fungi trap and kill nematodes using specialized trapping devices, which are highly efficient and non-toxic...