AbstractSTUDY QUESTIONDo the genetic determinants of idiopathic severe spermatogenic failure (SPGF) differ between generations?SUMMARY ANSWEROur data support that the genetic component of idiopathic SPGF is impacted by dynamic changes in environmental exposures over decades.WHAT IS KNOWN ALREADYThe idiopathic form of SPGF has a multifactorial etiology...

AbstractSTUDY QUESTIONDoes treatment selection for cervical lesions affect the outcome of IVF/ICSI?SUMMARY ANSWERThere was no difference in pregnancy outcome between treated and untreated groups, or between different types of IVF/ICSI treatment.WHAT IS KNOWN ALREADYHuman papillomavirus (HPV) infection and HPV-induced cervical lesions are associated...

AbstractSTUDY QUESTIONIs there any methylome alteration in women with PCOS who were diagnosed using the new international evidence-based guidelines?SUMMARY ANSWERA total of 264 differentially methylated probes (DMPs) and 53 differentially methylated regions (DMRs) were identified in patients with PCOS and healthy controls.WHAT IS KNOWN ALREADYPCOS is...

In 1988, the first IVF and embryo transfer infant was born on the Chinese mainland. For over 30 years, ART in China has developed rapidly. At present, the number of ART cycles (including IVF and artificial insemination) has exceeded 1 million per year in China, accounting for ∼3% of the total number of ART cycles in globe (Bai et al., 2020). The number...

AbstractSTUDY QUESTIONAre variants of genes involved in meiosis initiation responsible for premature ovarian insufficiency (POI)?SUMMARY ANSWERA MEIOSIN variant participates in the pathogenesis of human POI by impairing meiosis due to insufficient transcriptional activation of essential meiotic genes.WHAT IS KNOWN ALREADYMeiosis is the key event for...

AbstractSTUDY QUESTIONWas polycystic ovary syndrome (PCOS), which impairs fertility and adheres to the evolutionary paradox, subject to evolutionary selection during ancestral times and did rapidly diminish in prevalence?SUMMARY ANSWERThis study strengthened the hypothesis that positive selection of genetic variants occurred and may account for the...