Phoenixin (PNX) is a peptide that had been linked to the control of reproduction and energy homeostasis but the homozygous knockout (KO) of PNX did not impact fertility or the amount of weight gained on a high fat diet, possibly due to compensation. PNX has also been demonstrated to have anti-inflammatory effects in vivo and in vitro but we found...

Journal of Neuroendocrinology, Volume 36, Issue 5, May 2024.

Abstract Psychosocial stress negatively impacts reproductive function by inhibiting pulsatile luteinizing hormone (LH) secretion. The posterodorsal medial amygdala (MePD) is responsible in part for processing stress and modulating the reproductive axis. Activation of the neurokinin 3 receptor (NK3R) suppresses the gonadotropin-releasing hormone (GnRH)...

Abstract Somatostatin receptor positron emission tomography with computerised tomography imaging (SRI) has a high sensitivity for the detection of small intestinal neuroendocrine tumors (siNET), which makes it ideal for follow-up. The aim of the present study was to investigate whether follow-up with SRI in patients with siNET led to any change in...

Oxytocin (OT) is a promising therapeutic target for several disorders, but encouraging results found in rodents failed to translate to the clinic yet. To fill this gap of knowledge between rodents and primates, we mapped OT fibers throughout the marmoset monkey brain. We found extensive projections in the forebrain and brainstem, similarly to the...

Anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis, characterized by an autoimmune response against PIT-1, typically presents with undetectable GH and PRL levels, along with significantly low serum TSH levels at diagnosis. Given the limited number of previously reported cases of anti-PIT-1 hypophysitis and its manifestation with complete...