by Xueyao Wu, Changfeng Xiao, Danielle Rasooly, Xunying Zhao, Cynthia Casson Morton, Xia Jiang, C. Scott Gallagher Age at first sexual intercourse (AFS) and lifetime number of sexual partners (NSP) may influence the pathogenesis of uterine leiomyoma (UL) through their associations with hormonal concentrations and uterine infections. Leveraging...

by Tomáš Najer, Jorge Doña, Aleš Buček, Andrew D. Sweet, Oldřich Sychra, Kevin P. Johnson While mitochondrial genome content and organization is quite diverse across all Eukaryotes, most bilaterian animal mitochondrial genomes (mitogenomes) exhibit highly conserved gene content and organisation, with genes typically encoded on a single circular...

by Aravindh Nagarajan, Kristin Scoggin, Jyotsana Gupta, Manuchehr Aminian, L. Garry Adams, Michael Kirby, David Threadgill, Helene Andrews-Polymenis Staphylococcus aureus (S. aureus) is an opportunistic pathogen causing diseases ranging from mild skin infections to life threatening conditions, including endocarditis, pneumonia, and sepsis. To identify...

by Isabella Schember, William Reid, Geyenna Sterling-Lentsch, Marc S. Halfon Transcriptional cis-regulatory modules, e.g., enhancers, control the time and location of metazoan gene expression. While changes in enhancers can provide a powerful force for evolution, there is also significant deep conservation of enhancers for developmentally important...

by Elizabeth L. Graham, Joel Fernandez, Shagun Gandhi, Iqra Choudhry, Natalia Kellam, Jeannine R. LaRocque Accurate repair of DNA double-strand breaks (DSBs) is essential for the maintenance of genome integrity, as failure to repair DSBs can result in cell death. The cell has evolved two main mechanisms for DSB repair: non-homologous end-joining...

by Francois D. Rouleau, Alexandre K. Dubé, Isabelle Gagnon-Arsenault, Soham Dibyachintan, Alicia Pageau, Philippe C. Després, Patrick Lagüe, Christian R. Landry Pneumocystis jirovecii is a fungal pathogen that causes pneumocystis pneumonia, a disease that mainly affects immunocompromised individuals. This fungus has historically been hard to study...