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A tale of two lipids

Nature Chemical Biology, Published online: 21 February 2024; doi:10.1038/s41589-024-01577-6A tale of two lipids

Wed Feb 21, 2024 13:22
Lights on for lipid metabolism

Nature Chemical Biology, Published online: 21 February 2024; doi:10.1038/s41589-024-01575-8Lights on for lipid metabolism

Wed Feb 21, 2024 13:22
Death pools

Nature Chemical Biology, Published online: 21 February 2024; doi:10.1038/s41589-024-01576-7Death pools

Wed Feb 21, 2024 13:22
The druggability of SH2 domains unmasked

Nature Chemical Biology, Published online: 15 February 2024; doi:10.1038/s41589-024-01557-wDeveloping inhibitors for SH2 domains is challenging due to their shallow pockets and highly charged ligands. Structure-guided drug design has enabled the discovery of a cell-permeable covalent inhibitor of the SOCS2 SH2 domain, a key regulator of cytokine signaling...

Thu Feb 15, 2024 13:00
Post-translational glycosylation diminishes α-synuclein pathology formation

Nature Chemical Biology, Published online: 14 February 2024; doi:10.1038/s41589-024-01553-0O-linked N-acetylglucosamine (O-GlcNAc) is an endogenous form of glycosylation that alters the structure of α-synuclein amyloid fibrils and attenuates their pathogenetic properties. The modified fibrils have a significantly reduced ability to seed the aggregation...

Wed Feb 14, 2024 21:55
An intramolecular macrocyclase in plant ribosomal peptide biosynthesis

Nature Chemical Biology, Published online: 14 February 2024; doi:10.1038/s41589-024-01552-1BURP-domain proteins are an unexplored family of plant-specific, copper-dependent peptide cyclases. Here the authors show that a BURP-domain protein has a particular protein fold, investigate its mechanism and provide evidence for intramolecular modification in...

Wed Feb 14, 2024 12:57

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