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Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1

Nature Chemical Biology, Published online: 15 April 2021; doi:10.1038/s41589-021-00783-wA substrate-biased activity-based probe technology was developed to enable relatively facile identification of proteases responsible for specific proteolytic events in complex biological milieu, revealing that urokinase regulates CDCP1 proteolysis.

Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1

Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

Nature Chemical Biology, Published online: 12 April 2021; doi:10.1038/s41589-021-00776-9A CRISPR–Cas9 screen combined with heparan sulfate (HS)-binding reagents identifies genes involved in HS biosynthesis and assembly and reveals the unexpected role of histone demethylase KDM2B in regulating HS presentation on the cell surface.

Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

Hydrogel-based biocontainment of bacteria for continuous sensing and computation

Nature Chemical Biology, Published online: 05 April 2021; doi:10.1038/s41589-021-00779-6A dual-layer encapsulation approach provides physical containment of genetically modified bacteria (especially when combined with chemical containment) while also protecting them from environmental stressors and maintaining their sensing functions.

Hydrogel-based biocontainment of bacteria for continuous sensing and computation

The HaloTag as a general scaffold for far-red tunable chemigenetic indicators

Nature Chemical Biology, Published online: 01 April 2021; doi:10.1038/s41589-021-00775-wCombining the self-labeling HaloTag protein with synthetic environmentally sensitive fluorophores provides a platform for the construction of bright, far-red fluorescent calcium and voltage sensors with tunable photophysical and chemical properties.

The HaloTag as a general scaffold for far-red tunable chemigenetic indicators

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

Nature Chemical Biology, Published online: 25 March 2021; doi:10.1038/s41589-021-00774-xAlterations in the interactions driving phase separation of the mRNA decapping complex led to conformational rearrangements in its active site, providing a mechanism to control whether substrate mRNA is stored or decapped in condensates.

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

Nature Chemical Biology, Published online: 25 March 2021; doi:10.1038/s41589-021-00770-1Lysosome-targeting chimeras (LYTACs) based on glycan ligands of the asialoglycoprotein receptor facilitate the cell-specific targeting and turnover of proteins by lysosomal enzymes, expanding the scope of LYTAC-mediated targeted protein degradation.

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