Reconstruction of evolving gene variants and fitness from short sequencing reads

Nature Chemical Biology, Published online: 11 October 2021; doi:10.1038/s41589-021-00876-6Using short-read sequencing data, Evoracle reconstructs full-length genotypes and fitness during directed evolution experiments, and can identify low-frequency variants before they can be identified using consensus mutations.

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Reconstruction of evolving gene variants and fitness from short sequencing reads

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Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases

Nature Chemical Biology, Published online: 06 October 2021; doi:10.1038/s41589-021-00882-8Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases

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Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases

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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth

Nature Chemical Biology, Published online: 06 October 2021; doi:10.1038/s41589-021-00905-4Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth

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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth

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Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis

Nature Chemical Biology, Published online: 04 October 2021; doi:10.1038/s41589-021-00875-7TIP60-mediated crotonylation of the microtubule plus-end tracking protein EB1 at Lys66 regulates attachment of astral microtubules to the lateral cell cortex and spindle positioning.

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Crotonylation directs the spindle

Nature Chemical Biology, Published online: 04 October 2021; doi:10.1038/s41589-021-00881-9Controlled positioning of the mitotic spindle is key to tissue development and homeostasis. A recent study uncovered an EB1 crotonylation event that orchestrates microtubule dynamics in late mitosis, thus ensuring correct division orientation in vertebrate cells.

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Crotonylation directs the spindle

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Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis

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