Nature Chemical Biology, Published online: 08 May 2024; doi:10.1038/s41589-024-01607-3Ferroptosis, a cell death mechanism induced by lipid peroxidation, is pivotal in tumor suppression. A recent study shows that tumor repopulating cells evade ferroptosis and develop resistance to therapy via subverting a lipid metabolism enzyme.

Nature Chemical Biology, Published online: 08 May 2024; doi:10.1038/s41589-024-01612-6Phosphorylation of ACSL4 by mitochondria-located metabolic kinase PCK2 is critical to regulating ferroptosis-associated phospholipid remodeling in tumor-repopulating cells that are resistant to chemotherapy and radiotherapy.

Nature Chemical Biology, Published online: 06 May 2024; doi:10.1038/s41589-024-01610-8We present a discovery pipeline integrating chemical fragment screening and time-resolved, high-throughput small-angle X-ray scattering (TR-HT-SAXS). This approach identifies allosteric chemical leads targeting distinct allosteric states of the mitochondrial oxidoreductase...

Nature Chemical Biology, Published online: 03 May 2024; doi:10.1038/s41589-024-01593-6CRISPR–Cas13 systems use single-subunit RNA-guided Cas13 effectors for targeted RNA recognition and cleavage. This Review summarizes the recent advances in understanding the structural and mechanistic aspects of Cas13 systems and the diverse applications of these systems...

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01615-3Engineering from evolution

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01616-2Bacteria lose a pep in their step